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Molecular Therapy Advanced Specialist

Job Reference: 918-HM5132

Employer:
NHS Blood and Transplant (NHSBT)
Department:
CBC
Location:
Bristol
Salary:
£37,570 to £43,772 pa

The Clinical Biotechnology Centre (CBC), part of Cellular and Molecular Therapies (CMT) of NHSBT, is a specialist manufacturer of advanced therapies including both the production and testing of novel recombinant proteins and gene therapy products for clinical trials. CBC also has a product development department working with a number of external partners to translate R&D to the clinic. For example, CBC has recently embarked on a multi-centre collaboration with Imperial College London to establish a hub aiding the development, manufacturing and clinical transfer of novel vaccine platforms. The CBC has started construction of a novel state-of-the-art manufacturing centre in Filton (Bristol, UK). The post holder will join the viral vector development group in order to establish cGMP production of viral vectors for cell and gene therapy applications supporting early-stage clinical trials from the development stage into GMP-manufacturing in the new facility. The new bespoke facility will be closely embedded within other departments within Cellular and Molecular Therapies and will profit from close collaboration taking therapies from the molecular to the cellular stage for clinical trials.

 

The post holder will be responsible for development work in establishing lentiviral vector processing initially, extending into other types of vectors and including the accompanying quality control assays. An understanding of the quality control requirements for process and product qualification to GMP is essential. A strong practical background, preferably involving post-doctoral projects in viral vector processing (upstream processing, process monitoring and in-process analytical testing, downstream processing and formulation), is required.

 

The post holder will be required to travel to other NHSBT and external organisations.

 

Reporting directly to the Lead Development Scientist, the post holder will be responsible for the planning and monitoring of development and QC work and also actively participate in reporting and meetings internally and with collaborators.

 

The normal working hours for this role are 37.5 hours per week, Monday – Friday.

 

If you would like to discuss this vacancy in more detail, please contact Piers Walser (piers.walser@nhsbt.nhs.uk).

 

This vacancy will close at 23:59 on 29th January 2020.




NHS Blood and Transplant (NHSBT) offers a dynamic and friendly working environment where teamwork is highly valued. Personal development is also considered a priority and is supported through extensive training and development opportunities open to all employees.

We’re an inclusive organisation that reflects the diverse communities we work with and positively encourage applications from all sectors of the community.

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