Job summary
We are looking for a motivated Clinical research Fellow to join Dr Malick Gibani's team in the Department of Infectious Disease, to support the delivery of the PAiNTS study.
The PAiNTS study, funded by the Wellcome Trust, is clinical research building upon the successful development of the first human challenge model (CHANTS) for non-typhoidal Salmonella (NTS). This study will explore a re-challenge model and provide unparalleled ability to investigate the dynamics of the immune response to N
Main duties of the job
You will be a key member of the multi-disciplinary team,
working closely with clinical research fellows, clinical research nurses and
other scientists. One of your principal roles will be the management and
delivery of a human challenge and re-challenge model including recruitment and
screening, providing day-to-day clinical care of trial participants,
over-seeing trial records, data entry and analysis. You will develop your own
research skills and interests in the field of clinical microbiology, immunology
and vaccinology, aligned with the scientific direction of the PAiNTS consortium.
You will also be expected to write high quality manuscripts for rapid and
high-impact publication and to present findings at national and internation
conferences.
About us
Welcome to Imperial, a global top ten university where scientific imagination leads to world-changing impact.
Join us and be part of something bigger. From global health to climate change, AI to business leadership, we navigate some of the world's toughest challenges. Whatever your role, your contribution will have a lasting impact.
As a member of our vibrant community of 22,000 students and 8,000 staff, you'll collaborate with passionate minds across nine London campuses and a global network.
This is your chance to help shape the future. We hope you'll join us at Imperial.
Job description
Job responsibilities
Assisting with the day-to-day management and delivery of a human challenge model of Salmonella as part of the PAiNTS program.
- Co-ordinating the development of the study protocol and associated study documentation.
Assist with recruitment and screening of healthy volunteers into a human challenge model of non-typhoidal Salmonella.
Providing direct clinical liaison with the research nurses co-responsible for recruiting and caring for the enrolled patients.
Providing direct clinical care to study participants admitted for bacterial challenge, in liaison with the research nurses, the study PI and clinical steering group.
- Acting as a point of contact for study participants to provide clinical advice and care before, during and after challenge, under the supervision of the study PI and clinical steering group.
- Preparing data and safety reports and briefings for the data safety monitoring committee.
- Working with the team, in particular the lead research nurse and trial project manager, to ensure all the clinical research conducted is compliant with Good Clinical Practice.
- Training of study associated personnel.
- Ensuring adherence to the study protocol and compliance with regulatory requirements.
- Problem solving, maintaining and developing good relationships with researchers and clinicians associated with the study in a variety of different settings.
- Providing medical advice on the management of Salmonella infection to research nurses and participants.
- Supporting delivery of other clinical studies (including trials) within the Infection and AMR theme of the Imperial College Biomedical Research Centre.
- Identifying and developing further research ideas which could be nested within the studies.
- Developing their own research skills and technical expertise and interests in the field of clinical microbiology, immunology and vaccinology, aligned with the scientific direction of the PAiNTS consortium.
- To conduct data analysis
- To ensure the validity and reliability of data at all times
- To present findings to colleagues and at conferences
- To submit publications to refereed journals
Other Duties:
- To undertake any necessary training and/or development
- To undertake appropriate administration tasks
- To attend relevant meetings
Job description
Job responsibilities
Assisting with the day-to-day management and delivery of a human challenge model of Salmonella as part of the PAiNTS program.
- Co-ordinating the development of the study protocol and associated study documentation.
Assist with recruitment and screening of healthy volunteers into a human challenge model of non-typhoidal Salmonella.
Providing direct clinical liaison with the research nurses co-responsible for recruiting and caring for the enrolled patients.
Providing direct clinical care to study participants admitted for bacterial challenge, in liaison with the research nurses, the study PI and clinical steering group.
- Acting as a point of contact for study participants to provide clinical advice and care before, during and after challenge, under the supervision of the study PI and clinical steering group.
- Preparing data and safety reports and briefings for the data safety monitoring committee.
- Working with the team, in particular the lead research nurse and trial project manager, to ensure all the clinical research conducted is compliant with Good Clinical Practice.
- Training of study associated personnel.
- Ensuring adherence to the study protocol and compliance with regulatory requirements.
- Problem solving, maintaining and developing good relationships with researchers and clinicians associated with the study in a variety of different settings.
- Providing medical advice on the management of Salmonella infection to research nurses and participants.
- Supporting delivery of other clinical studies (including trials) within the Infection and AMR theme of the Imperial College Biomedical Research Centre.
- Identifying and developing further research ideas which could be nested within the studies.
- Developing their own research skills and technical expertise and interests in the field of clinical microbiology, immunology and vaccinology, aligned with the scientific direction of the PAiNTS consortium.
- To conduct data analysis
- To ensure the validity and reliability of data at all times
- To present findings to colleagues and at conferences
- To submit publications to refereed journals
Other Duties:
- To undertake any necessary training and/or development
- To undertake appropriate administration tasks
- To attend relevant meetings
Person Specification
Qualifications
Essential
- Clinically qualified (MBBS or equivalent) and GMC registered.
- Membership of the Royal College of Physicians, or equivalent.
- Certification in Advanced Life Support (ALS) or equivalent.
Desirable
- Specialist trainee (in infection, microbiology, gastroenterology, or internal medicine). Advanced Internal medicine trainees (e.g., IMT3) with MRCP (or equivalent) applicants will also be considered.
Experience
Essential
- Significant clinical experience in general internal medicine and the management of bacterial infection
- Experience of coordinating, organising, and conducting clinical research
- Working knowledge of UK clinical trials regulations, principles of GCP, UK GDPR and Research Governance Framework legislation and proven ability to apply these to the coordination of clinical trials
Desirable
- Significant experience in clinical microbiology
- Willingness to develop laboratory skills including immunological and microbiological assays
- Understanding of human challenge study methodology
Person Specification
Qualifications
Essential
- Clinically qualified (MBBS or equivalent) and GMC registered.
- Membership of the Royal College of Physicians, or equivalent.
- Certification in Advanced Life Support (ALS) or equivalent.
Desirable
- Specialist trainee (in infection, microbiology, gastroenterology, or internal medicine). Advanced Internal medicine trainees (e.g., IMT3) with MRCP (or equivalent) applicants will also be considered.
Experience
Essential
- Significant clinical experience in general internal medicine and the management of bacterial infection
- Experience of coordinating, organising, and conducting clinical research
- Working knowledge of UK clinical trials regulations, principles of GCP, UK GDPR and Research Governance Framework legislation and proven ability to apply these to the coordination of clinical trials
Desirable
- Significant experience in clinical microbiology
- Willingness to develop laboratory skills including immunological and microbiological assays
- Understanding of human challenge study methodology
Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
