Job summary
Your role will focus on a project entitled 'Investigation of the on-chromatin mechanisms of oncogenic transcriptome regulation by CCND1 in multiple myeloma'. You will be involved in core experimental approaches, including epigenetic analyses such as ChIP-seq, RNA- and TT-seq, ATAC-seq and Capture-C, use of in vitro and in vivo models of myeloma, and a variety of molecular techniques including gene editing and protein degradation by degron technology
Main duties of the job
You will perform experimental work as per the requirements of the project. For this purpose, you will receive training and supervision at the bench and have the opportunity to develop the computational skills necessary to analyse the variety of -omics data that you will generate during your project.
You will be expected to work closely with scientists of all seniorities and contribute to the running of the lab, organise, curate and annotate your data, make regular presentations at laboratory and departmental research meetings.
You will be expected to attend a number of College training courses; you will register for a PhD, submit early and late stage assessment reports and also engage with the project funder, providing progress updates and additional communications as required. You will liaise with clinicians of the Myeloma Service to co-ordinate collection of clinical samples for molecular analysis and will be involved and develop PPIE activities.
You must be organised, highly self-motivated and have excellent communication, interpersonal and computer skills. You will need to manage your time and performance, must be strongly proactive, knowledgeable, and able to solve complex problems.
About us
As part of this role, You will register for and pursue a higher research degree (PhD) in a leading academic haematology centre under the supervision of Prof Tassos Karadimitris and Dr Nick Crump at the Hugh and Josseline Langmuir Centre for Myeloma Research, Centre for Haematology, Department of Immunology and Inflammation. You will join a dynamic group of clinical and non-clinical scientists of all levels of seniority to pursue research pertinent to functional genomics of multiple myeloma.
Job description
Job responsibilities
Job summary
We are seeking applications from pre-CCT haematology trainees, including academic clinical fellows, for a full time three-year Clinical Research Fellowship funded by the Matthew Wilson Multiple Myeloma Fund and Blood Cancer UK.
As part of this role, You will register for and pursue a higher research degree (PhD) in a leading academic haematology centre under the supervision of Prof Tassos Karadimitris and Dr Nick Crump at the Hugh and Josseline Langmuir Centre for Myeloma Research, Centre for Haematology, Department of Immunology and Inflammation. You will join a dynamic group of clinical and non-clinical scientists of all levels of seniority to pursue research pertinent to functional genomics of multiple myeloma.
Your role will focus on a project entitled 'Investigation of the on-chromatin mechanisms of oncogenic transcriptome regulation by CCND1 in multiple myeloma'. You will be involved in core experimental approaches, including epigenetic analyses such as ChIP-seq, RNA- and TT-seq, ATAC-seq and Capture-C, use of in vitro and in vivo models of myeloma, and a variety of molecular techniques including gene editing and protein degradation by degron technology
Duties and responsibilities
You will perform experimental work as per the requirements of the project. For this purpose, you will receive training and supervision at the bench and have the opportunity to develop the computational skills necessary to analyse the variety of -omics data that you will generate during your project.
You will be expected to work closely with scientists of all seniorities and contribute to the running of the lab, organise, curate and annotate your data, make regular presentations at laboratory and departmental research meetings.
You will be expected to attend a number of College training courses; you will register for a PhD, submit early and late stage assessment reports and also engage with the project funder, providing progress updates and additional communications as required. You will liaise with clinicians of the Myeloma Service to co-ordinate collection of clinical samples for molecular analysis and will be involved and develop PPIE activities.
You must be organised, highly self-motivated and have excellent communication, interpersonal and computer skills. You will need to manage your time and performance, must be strongly proactive, knowledgeable, and able to solve complex problems.
Essential requirements
MBBS or equivalent with full valid GMC Registration and hold a licence to practisePre-CCT Haematology trainee level of experienceKnowledge of haemato-oncologyAbility to develop and apply new concepts; ability to formulate research questions and design appropriate experimental approaches
Further information
This is a full-time, fixed-term role, until 30 September 2026. It is based at Imperial's Hammersmith Campus in East Acton.
Should you require any further details on the role, please contact Tassos Karadimitris () and Nick Crump ()
Imperial College is committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment. We are an Athena SWAN Silver award winner, a Stonewall Diversity Champion, a Disability Confident Employer and work in partnership with GIRES to promote respect for trans people.
Closing date: DD/MM/YYYY
To apply, visit www.imperial.ac.uk/jobs and search by the job reference
Job description
Job responsibilities
Job summary
We are seeking applications from pre-CCT haematology trainees, including academic clinical fellows, for a full time three-year Clinical Research Fellowship funded by the Matthew Wilson Multiple Myeloma Fund and Blood Cancer UK.
As part of this role, You will register for and pursue a higher research degree (PhD) in a leading academic haematology centre under the supervision of Prof Tassos Karadimitris and Dr Nick Crump at the Hugh and Josseline Langmuir Centre for Myeloma Research, Centre for Haematology, Department of Immunology and Inflammation. You will join a dynamic group of clinical and non-clinical scientists of all levels of seniority to pursue research pertinent to functional genomics of multiple myeloma.
Your role will focus on a project entitled 'Investigation of the on-chromatin mechanisms of oncogenic transcriptome regulation by CCND1 in multiple myeloma'. You will be involved in core experimental approaches, including epigenetic analyses such as ChIP-seq, RNA- and TT-seq, ATAC-seq and Capture-C, use of in vitro and in vivo models of myeloma, and a variety of molecular techniques including gene editing and protein degradation by degron technology
Duties and responsibilities
You will perform experimental work as per the requirements of the project. For this purpose, you will receive training and supervision at the bench and have the opportunity to develop the computational skills necessary to analyse the variety of -omics data that you will generate during your project.
You will be expected to work closely with scientists of all seniorities and contribute to the running of the lab, organise, curate and annotate your data, make regular presentations at laboratory and departmental research meetings.
You will be expected to attend a number of College training courses; you will register for a PhD, submit early and late stage assessment reports and also engage with the project funder, providing progress updates and additional communications as required. You will liaise with clinicians of the Myeloma Service to co-ordinate collection of clinical samples for molecular analysis and will be involved and develop PPIE activities.
You must be organised, highly self-motivated and have excellent communication, interpersonal and computer skills. You will need to manage your time and performance, must be strongly proactive, knowledgeable, and able to solve complex problems.
Essential requirements
MBBS or equivalent with full valid GMC Registration and hold a licence to practisePre-CCT Haematology trainee level of experienceKnowledge of haemato-oncologyAbility to develop and apply new concepts; ability to formulate research questions and design appropriate experimental approaches
Further information
This is a full-time, fixed-term role, until 30 September 2026. It is based at Imperial's Hammersmith Campus in East Acton.
Should you require any further details on the role, please contact Tassos Karadimitris () and Nick Crump ()
Imperial College is committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment. We are an Athena SWAN Silver award winner, a Stonewall Diversity Champion, a Disability Confident Employer and work in partnership with GIRES to promote respect for trans people.
Closing date: DD/MM/YYYY
To apply, visit www.imperial.ac.uk/jobs and search by the job reference
Person Specification
Qualifications
Essential
- MBBS or equivalent with full valid GMC Registration and hold a licence to practise
Desirable
- Postgraduate specialist qualification e.g. MRCP or equivalent
Experience
Essential
- Pre-CCT Haematology trainee level of experience
- Knowledge of haemato-oncology
Desirable
- Academic Clinical Fellow post
Person Specification
Qualifications
Essential
- MBBS or equivalent with full valid GMC Registration and hold a licence to practise
Desirable
- Postgraduate specialist qualification e.g. MRCP or equivalent
Experience
Essential
- Pre-CCT Haematology trainee level of experience
- Knowledge of haemato-oncology
Desirable
- Academic Clinical Fellow post
Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the UK Visas and Immigration website (Opens in a new tab).
From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab).
UK Registration
Applicants must have current UK professional registration. For further information please see
NHS Careers website (opens in a new window).
Additional information
Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the UK Visas and Immigration website (Opens in a new tab).
From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab).
UK Registration
Applicants must have current UK professional registration. For further information please see
NHS Careers website (opens in a new window).
