UK Health Security Agency

Project Team Leader

The closing date is 11 November 2025

Job summary

The Pre-clinical Evaluation Team is a translational research group within the wider Countermeasures Development, Evaluation, and Preparedness Division (CDEP), at UKHSA Porton Down, investigating high consequence human pathogens.

Research undertaken in the team includes development and application of in vivo models, assays to advance the testing of vaccines, and investigation of organ-on-chip technology as an adjunct to our existing capabilities. A range of roles are available within the department. These include leading on the implementation of organ on chip models for the study of severe study of severe human infections and the infections and the efficacy of candidate therapeutics, managing the delivery of in-vivo studies some of which may be performed to a higher quality standard or directing the development of assays to measure immunogenicity and/or efficacy in samples collected during in vivo studies.

We are currently recruiting for 1 post with the potential for further posts becoming available in the near future.

Main duties of the job

The post holder will:

  • lead their own projects, contribute to other projects on a collaborative basis (both in the team and with external collaborators) and be responsible for the delivery of the scientific and technical activities within the Pre-clinical Evaluation Team.
  • have a relevant PhD (or equivalent and/or experience) in virology, cell biology or immunology. They will demonstrate the ability to develop and undertake a broad range of cell biology, virological and immunological techniques (specifically assessment of cellular immunity) that support the characterisation of in vivo or in-vitro models of disease.
  • have good communication skills, good attention to detail, and strong documentation and organisation skills.
  • Previous experience of managing individuals or a small team, working with external collaborators/customers and/or working at containment level 3 would be desirable although full training and support will be given.
  • be expected to be flexible to the demands of the project, have excellent communication skills and use their technical experience to lead a small team and ensure delivery of their project area.

About us

We pride ourselves as being an employer of choice, where Everyone Matters promoting equality of opportunity to actively encourage applications from everyone, including groups currently underrepresented in our workforce.

UKHSA ethos is to be an inclusive organisation for all our staff and stakeholders. To create, nurture and sustain an inclusive culture, where differences drive innovative solutions to meet the needs of our workforce and wider communities. We do this through celebrating and protecting differences by removing barriers and promoting equity and equality of opportunity for all.

Please visit our careers site for more information https://gov.uk/ukhsa/careers

Details

Date posted

28 October 2025

Pay scheme

Other

Salary

£41,983 to £48,128 a year per annum, pro rata

Contract

Permanent

Working pattern

Full-time, Part-time, Job share, Flexible working

Reference number

919-GB-62203859-EXT

Job locations

Porton

Porton

SP4 0JG


Job description

Job responsibilities

Main duties include:

  • Managing projects and studies to meet agreed deadlines.
  • Implementing and using a range of methods/assays in support of all activities associated with the project
  • Monitoring direct reports objectives and performance to ensure project targets are met.
  • Taking the responsibility for checking, compiling and reporting project data to stakeholders including external customers.
  • Leading a project team in identifying, evaluating, and adapting new technologies and methods where appropriate and to ensure that the project operates to a high scientific standard using current methods.
  • Establishing links and collaborations within and outside UKHSA as necessary to benefit the project and/or department.
  • Supporting members of the project team to meet their PDP objectives and take lead responsibility for the supervision and training of junior staff allocated to the project.
  • Ensuring that the project team undertakes work in accordance with UKHSAs Code of Safety Practice and working within any Quality Systems that are applicable to the site.
  • Maintaining health and safety competence to the national occupational standard Make sure your actions reduce risks to health and safety (NOS HSS1).
  • Identifying, discussing, and actioning own professional performance and training / development needs with line manager
  • Performing any other duties required by the Line manager commensurate with grade.
  • Undertaking risk assessor role, with associated training and ongoing competency

Essential role criteria

  • PhD, or BSc/MSc with several years experience in biological science/virology/immunology subject.
  • Experience working with primary cells on transwells and/or organ-on-chip devices or in vivo models of infectious disease or developing and troubleshooting virology/immunological assays.
  • Good understanding and experience of analytical methods that are relevant to the project area e.g., bioassays, immunological assays (flow cytometric/cellular) and/or virological assays.
  • Experience of leading projects/project teams and training less-experienced members of staff.
  • Knowledge and experience of practices and principles of working at ADCP containment level 3 or willing to undertake training to become competent to work at ACDP containment level 3.
  • Strong communicator capable of constructing and delivering clear ideas and concepts concisely and accurately for diverse audiences.
  • Ability to prioritise the workload of the team and anticipate the needs of the projects you manage to ensure that project targets and deadlines are met.
  • Ability to exercise good judgement in solving problems and making effective decisions, using knowledge, intuition and comprehensive situational awareness.
  • Excellent team working skills with the ability to motivate and support the project team to effectively complete project objectives as well as their own personal development objectives.
  • Ability to cope, and help others cope, with uncertainty, change and often tight timelines. Be adaptable and work flexibly to meet deadlines.
  • An understanding of and commitment to equality of opportunity and good working relationships.
  • Experience of complex data analysis, presentations, reports, and publications.

Desirable role criteria:

  • Experience in the use of organ-on-chip technologies/ex vivo 3D culture systems, delivering in-vivo studies or developing assays such as performing polychromatic flow cytometric assays.
  • Demonstrable experience of having worked within a regulated environment (e.g., GCP, ISO9001) and undergoing audits
  • Skills in networking with the ability to nurture and maintain key relationships both within the organisation and with external customers.

Selection Process Details:

This vacancy is using Success Profiles and will assess your Behaviours and Experience.

Stage 1: Application & Sift

You will be required to complete an application form. You will be assessed on the listed (12) essential criteria, and this will be in the form of a:

  • Application form (Employer/ Activity history section on the application)
  • up to 1000 wordsupporting statement.

This should outline how your skills, experience, and knowledge, provide evidence of your suitability for the role, with reference to the essential criteria.

The Application form and supporting statement will be marked together.

Longlisting:

In the event of a large number of applications we will longlist into 3 piles of:

  • Meets all essential criteria
  • Meets some essential criteria
  • Meets no essential criteria

The following will be taken through to the next stage:

  • Meets all essential criteria
  • Meets some essential criteria

Shortlisting:

In the event of a large number of applications we will shortlist on the following:

  • PhD, or BSc/MSc with several years experience in biological science/virology/immunology subject.
  • Experience working with primary cells on transwells and/or organ-on-chip devices or in-vivo models of infectious disease or developing and troubleshooting virology/immunological assays.
  • Good understanding and experience of analytical methods that are relevant to the project area e.g., bioassays, immunological assays (flow cytometric/cellular) and/or virological assays.
  • Experience of leading projects/project teams and training less-experienced members of staff.

Desirable criteria may be used in the event of a large number of applications / large amount of successful candidates.

If you are successful at this stage, you will progress to interview & assessment

Please do not exceed .1000 words. We will not consider any words over and above this number.

Feedback will not be provided at this stage.

Please note you will not be able to upload your CV. You must complete the application form in as much detail as possible. Please do not email us your CV.

Stage 2: Interview (success profiles)

You will be invited to a (single) face to face interview. If face to face interviews are planned, in exceptional circumstances, we may be able to offer a remote interview.

Behaviours, and experience will be tested at interview.

The Behaviours tested during the interview stage will be:

  • Leadership
  • Making effective decisions
  • Communicating and Influencing - Lead behaviour
  • Developing self and others

Once this job has closed, the job advert will no longer be available. You may want to save a copy for your records.

Eligibility Criteria- External

Open to all external applicants (anyone) from outside the Civil Service (including by definition internal applicants).

Location

This role is an office based role at UKHSA Porton.Please note hybrid working is not available for this role.

Our core HQ offices are modern and newly refurbished with excellent city centre transport link and benefit from benefit from co-location with other government departments such as the Department for Health and Social Care (DHSC).Our core HQ offices are modern and newly refurbished with excellent city centre transport link and benefit from benefit from co-location with other government departments such as theDepartment for Health and Social Care (DHSC).

Security Clearance LevelRequirement

Successful candidates must pass a disclosure and barring security check.

Successful candidates must meet the security requirements before they can be appointed. The level of security needed is Security Clearance.

For meaningful National Security Vetting checks to be carried out individuals need to have lived in the UK for a sufficientperiod of time. You should normally have been resident in the United Kingdom for the last 5 years as the role requires Security Check (SC) clearance.UK residency less than the outlined periods may not necessarily bar you from gaining national security vetting and applicants should contact the Vacancy Holder / Recruiting Manager listed in the advert for further advice.

Job description

Job responsibilities

Main duties include:

  • Managing projects and studies to meet agreed deadlines.
  • Implementing and using a range of methods/assays in support of all activities associated with the project
  • Monitoring direct reports objectives and performance to ensure project targets are met.
  • Taking the responsibility for checking, compiling and reporting project data to stakeholders including external customers.
  • Leading a project team in identifying, evaluating, and adapting new technologies and methods where appropriate and to ensure that the project operates to a high scientific standard using current methods.
  • Establishing links and collaborations within and outside UKHSA as necessary to benefit the project and/or department.
  • Supporting members of the project team to meet their PDP objectives and take lead responsibility for the supervision and training of junior staff allocated to the project.
  • Ensuring that the project team undertakes work in accordance with UKHSAs Code of Safety Practice and working within any Quality Systems that are applicable to the site.
  • Maintaining health and safety competence to the national occupational standard Make sure your actions reduce risks to health and safety (NOS HSS1).
  • Identifying, discussing, and actioning own professional performance and training / development needs with line manager
  • Performing any other duties required by the Line manager commensurate with grade.
  • Undertaking risk assessor role, with associated training and ongoing competency

Essential role criteria

  • PhD, or BSc/MSc with several years experience in biological science/virology/immunology subject.
  • Experience working with primary cells on transwells and/or organ-on-chip devices or in vivo models of infectious disease or developing and troubleshooting virology/immunological assays.
  • Good understanding and experience of analytical methods that are relevant to the project area e.g., bioassays, immunological assays (flow cytometric/cellular) and/or virological assays.
  • Experience of leading projects/project teams and training less-experienced members of staff.
  • Knowledge and experience of practices and principles of working at ADCP containment level 3 or willing to undertake training to become competent to work at ACDP containment level 3.
  • Strong communicator capable of constructing and delivering clear ideas and concepts concisely and accurately for diverse audiences.
  • Ability to prioritise the workload of the team and anticipate the needs of the projects you manage to ensure that project targets and deadlines are met.
  • Ability to exercise good judgement in solving problems and making effective decisions, using knowledge, intuition and comprehensive situational awareness.
  • Excellent team working skills with the ability to motivate and support the project team to effectively complete project objectives as well as their own personal development objectives.
  • Ability to cope, and help others cope, with uncertainty, change and often tight timelines. Be adaptable and work flexibly to meet deadlines.
  • An understanding of and commitment to equality of opportunity and good working relationships.
  • Experience of complex data analysis, presentations, reports, and publications.

Desirable role criteria:

  • Experience in the use of organ-on-chip technologies/ex vivo 3D culture systems, delivering in-vivo studies or developing assays such as performing polychromatic flow cytometric assays.
  • Demonstrable experience of having worked within a regulated environment (e.g., GCP, ISO9001) and undergoing audits
  • Skills in networking with the ability to nurture and maintain key relationships both within the organisation and with external customers.

Selection Process Details:

This vacancy is using Success Profiles and will assess your Behaviours and Experience.

Stage 1: Application & Sift

You will be required to complete an application form. You will be assessed on the listed (12) essential criteria, and this will be in the form of a:

  • Application form (Employer/ Activity history section on the application)
  • up to 1000 wordsupporting statement.

This should outline how your skills, experience, and knowledge, provide evidence of your suitability for the role, with reference to the essential criteria.

The Application form and supporting statement will be marked together.

Longlisting:

In the event of a large number of applications we will longlist into 3 piles of:

  • Meets all essential criteria
  • Meets some essential criteria
  • Meets no essential criteria

The following will be taken through to the next stage:

  • Meets all essential criteria
  • Meets some essential criteria

Shortlisting:

In the event of a large number of applications we will shortlist on the following:

  • PhD, or BSc/MSc with several years experience in biological science/virology/immunology subject.
  • Experience working with primary cells on transwells and/or organ-on-chip devices or in-vivo models of infectious disease or developing and troubleshooting virology/immunological assays.
  • Good understanding and experience of analytical methods that are relevant to the project area e.g., bioassays, immunological assays (flow cytometric/cellular) and/or virological assays.
  • Experience of leading projects/project teams and training less-experienced members of staff.

Desirable criteria may be used in the event of a large number of applications / large amount of successful candidates.

If you are successful at this stage, you will progress to interview & assessment

Please do not exceed .1000 words. We will not consider any words over and above this number.

Feedback will not be provided at this stage.

Please note you will not be able to upload your CV. You must complete the application form in as much detail as possible. Please do not email us your CV.

Stage 2: Interview (success profiles)

You will be invited to a (single) face to face interview. If face to face interviews are planned, in exceptional circumstances, we may be able to offer a remote interview.

Behaviours, and experience will be tested at interview.

The Behaviours tested during the interview stage will be:

  • Leadership
  • Making effective decisions
  • Communicating and Influencing - Lead behaviour
  • Developing self and others

Once this job has closed, the job advert will no longer be available. You may want to save a copy for your records.

Eligibility Criteria- External

Open to all external applicants (anyone) from outside the Civil Service (including by definition internal applicants).

Location

This role is an office based role at UKHSA Porton.Please note hybrid working is not available for this role.

Our core HQ offices are modern and newly refurbished with excellent city centre transport link and benefit from benefit from co-location with other government departments such as the Department for Health and Social Care (DHSC).Our core HQ offices are modern and newly refurbished with excellent city centre transport link and benefit from benefit from co-location with other government departments such as theDepartment for Health and Social Care (DHSC).

Security Clearance LevelRequirement

Successful candidates must pass a disclosure and barring security check.

Successful candidates must meet the security requirements before they can be appointed. The level of security needed is Security Clearance.

For meaningful National Security Vetting checks to be carried out individuals need to have lived in the UK for a sufficientperiod of time. You should normally have been resident in the United Kingdom for the last 5 years as the role requires Security Check (SC) clearance.UK residency less than the outlined periods may not necessarily bar you from gaining national security vetting and applicants should contact the Vacancy Holder / Recruiting Manager listed in the advert for further advice.

Person Specification

Application form and statement of suitability

Essential

  • Application form and statement of suitability

Behaviours

Essential

  • Leadership
  • Making Effective Decisions
  • Communicating and Influencing - Lead behaviour
  • Developing self and others
Person Specification

Application form and statement of suitability

Essential

  • Application form and statement of suitability

Behaviours

Essential

  • Leadership
  • Making Effective Decisions
  • Communicating and Influencing - Lead behaviour
  • Developing self and others

Disclosure and Barring Service Check

This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.

Certificate of Sponsorship

Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the UK Visas and Immigration website (Opens in a new tab).

From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab).

Additional information

Disclosure and Barring Service Check

This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.

Certificate of Sponsorship

Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the UK Visas and Immigration website (Opens in a new tab).

From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab).

Employer details

Employer name

UK Health Security Agency

Address

Porton

Porton

SP4 0JG


Employer's website

https://www.gov.uk/government/organisations/uk-health-security-agency (Opens in a new tab)

Employer details

Employer name

UK Health Security Agency

Address

Porton

Porton

SP4 0JG


Employer's website

https://www.gov.uk/government/organisations/uk-health-security-agency (Opens in a new tab)

Employer contact details

For questions about the job, contact:

Resourcing

Gurkamal Bhambra

gurkamal.bhambra@ukhsa.gov.uk

Details

Date posted

28 October 2025

Pay scheme

Other

Salary

£41,983 to £48,128 a year per annum, pro rata

Contract

Permanent

Working pattern

Full-time, Part-time, Job share, Flexible working

Reference number

919-GB-62203859-EXT

Job locations

Porton

Porton

SP4 0JG


Supporting documents

Privacy notice

UK Health Security Agency's privacy notice (opens in a new tab)