Job summary
To lead new evaluations regarding pharmacokinetic and pharmacodynamic (PKPD) for pulmonary optimization within the PKPD laboratory (Research Microbiology Department).
To work closely with the Consultant respiratory physician and Head Research Scientist in the PKPD lab to ensure the management of simulations is of a high quality and to take responsibility for :
High quality data
MIC studies
Time Kill Curve evaluations
Immunoassay and liquid chromatographic assays, including the operation, maintenance and management of HPLC systems within the ARL laboratory.
Development of PKPD models
Method development of respiratory agents
Providing specialist microbiology susceptibility and molecular tests
The role will also include assistance in North Bristol Trusts NIHR CRN Portfolio and other microbiology research projects. The post holder will be required to work alone and participate in regular out of hours working
Main duties of the job
Practical responsibilities
Implement the setup and running and, quality assure the data generated from pharmacodynamic models as designed to investigate the interactions of antibiotics on bacteria in a research setting
Ensure accurate data collection and analysis as appropriate using Excel and Word and specialist software such as Graph Pad Prism.
Measurement, analysis and quality assure antimicrobial agents used in PK/PD studies by immunoassay, liquid chromatography or bio-assay
Perform tests to assess the susceptibility of bacteria to antibiotics by both routine and specialist techniques, including disc methods, agar and broth dilution methods, E test, and antibiotic - antibiotic interaction studies
To support the line manager in the delivery of Pharma, NBT and NIHR-CRN research projects
About us
North Bristol NHS Trust employs over 12,000 staff providing healthcare to the residents of Bristol, South Gloucestershire and North Somerset from our award-winning hospital building at Southmead. We are the regional Major Trauma Centre, and an internationally recognised centre of excellence in a range of services and major specialities. Our vision is that by enabling our teams to be the best that they can be, we will provide exceptional healthcare, personally delivered.
North Bristol NHS Trust values all people as individuals. We aim to be an anti-discriminatory organisation and are committed to building a team that represents a variety of backgrounds, perspectives, and skills. We welcome applicants from all underrepresented groups.
Job description
Job responsibilities
Knowledge
A relevant science degree, or post graduate degree with equivalent specialist experience
1 year practical experience in PKPD in vitro modelling, MIC scienceisessential
1 year practical and appropriate theoretical knowledge of analytical techniques including susceptibility testing; determination of resistance mechanisms and bacterial identification using molecular techniques
Experience working in a research team is essential
Able to maintain and demonstrate a high level of practical competence and willingness to undertake further training as required
Knowledge of laboratory polices, codes of practice and professional guidelines
Knowledge of health and safety issues pertinent to laboratory work
Skills
Under the direction of the Lead Research Clinical Scientist -
Organize the day to day running of the respiratory PKPD simulations
Undertake a range of diagnostic tests relevant to the area of work
Present data both written and oral including laboratory reports
Plan, prioritize, implement and evaluate own workload and workload for support team
Teach and supervise non-professionally qualified staff ( if required)
Use NBT Clerical and IT skills
Work independently and be able to develop good relationships with colleagues, and external collaborators.
Maintain and demonstrate a high level of practical competence and willingness to undertake further training as required
For further details / informal visits contact:
Job description
Job responsibilities
Knowledge
A relevant science degree, or post graduate degree with equivalent specialist experience
1 year practical experience in PKPD in vitro modelling, MIC scienceisessential
1 year practical and appropriate theoretical knowledge of analytical techniques including susceptibility testing; determination of resistance mechanisms and bacterial identification using molecular techniques
Experience working in a research team is essential
Able to maintain and demonstrate a high level of practical competence and willingness to undertake further training as required
Knowledge of laboratory polices, codes of practice and professional guidelines
Knowledge of health and safety issues pertinent to laboratory work
Skills
Under the direction of the Lead Research Clinical Scientist -
Organize the day to day running of the respiratory PKPD simulations
Undertake a range of diagnostic tests relevant to the area of work
Present data both written and oral including laboratory reports
Plan, prioritize, implement and evaluate own workload and workload for support team
Teach and supervise non-professionally qualified staff ( if required)
Use NBT Clerical and IT skills
Work independently and be able to develop good relationships with colleagues, and external collaborators.
Maintain and demonstrate a high level of practical competence and willingness to undertake further training as required
For further details / informal visits contact:
Person Specification
written
Essential
- PKPD practical experience
- Performed PhD studies
- Microbiology practical experience
- Experience of trouble shooting
Desirable
- Training experience
- Working as part as a team and independently
Verbal
Essential
Desirable
Person Specification
written
Essential
- PKPD practical experience
- Performed PhD studies
- Microbiology practical experience
- Experience of trouble shooting
Desirable
- Training experience
- Working as part as a team and independently
Verbal
Essential
Desirable
Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the UK Visas and Immigration website (Opens in a new tab).
From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab).
Additional information
Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the UK Visas and Immigration website (Opens in a new tab).
From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab).
