Job summary
We have an exciting opportunity that has arisen at the Antimicrobial Reference Laboratory based at North Bristol NHS Trust. Band 5 analyst to join a research and bioanalysis unit working on the development of new LCMS methods to test for various antibiotics in clinical samples as part of the department research portfolio.
We are looking for an individual who is eager to learn and keen to deliver in antimicrobial research. The post holder will work closely with the senior LCMS Bioanalyst and the head of the department to undertake, in collaboration with our industrial partners, the development and validation of LCMS assays and is expected to have some experience of day-to-day running of various LCMS systems.
The assays will be undertaken to the relevant standards (UKAS / MHRA) and the post holder will assist with preparing relevant documents and reports.
Please note: this is a two year fixed term position and will terminate when the grant ends or no further funding can be obtained.
Secondments from within the NHS will be considered.
Please see the job description and person specification for further information
Please see this short video showcasing Pathology at NBT.
https://youtu.be/cJiNgR-TwUY?si=H6kkwCD5FvSv6UpW
Main duties of the job
To conduct day-to-day analysis of research / trial samples to complete the projects within the designated timeframes.
Assist the Senior Bioanalytical Analyst with validation and use of LC-MS/MS assays in research support and regulatory work.
Ensure all work is conducted in compliance with the necessary laboratory standards and regulatory requirements with the assistance of local quality assurance (QA)
Please see the job description and person specification for further information
About us
The successful candidate would be working in a team of friendly, knowledgeable & experienced analytical scientists. They will be supported by the seniors within the section as well the head of the department as we have an open door policy which means the successful candidate can request a meeting with any of the managers at short notice.
North Bristol NHS trust is the largest healthcare provider in the south west of England, and this post is located in the Pathology sciences building which has a total capacity of over 500 staff members. There are various shops on site as well as a staff canteen and coffee shop. There are multiple meeting and seminar rooms available as well as staff library located approx. 2 min walk from the department.
Please visit North Bristol NHS trust website for more comprehensive information.
Job description
Job responsibilities
To participate in the provision of effective and high-quality analytical research for sections situated within the microbiology research department.To take responsibility for the day-to-day running of samples using HPLC and LC-MS/MS techniques, also to include the maintenance, operation, and management of these equipment.Under the direction of senior analysts and managers, assist in the LC-MS/MS analysis of Phase I and II clinical trials as part of the EU research programme.Ensure all work is conducted in compliance with the necessary regulatory standards including UKAS(for clinical samples) and GCLP (for clinical trials) also liaising with and supporting the Quality Officerin Quality related issues.Organisation Chart/Accountability
Please refer to the job description and person specification for further information.
Job description
Job responsibilities
To participate in the provision of effective and high-quality analytical research for sections situated within the microbiology research department.To take responsibility for the day-to-day running of samples using HPLC and LC-MS/MS techniques, also to include the maintenance, operation, and management of these equipment.Under the direction of senior analysts and managers, assist in the LC-MS/MS analysis of Phase I and II clinical trials as part of the EU research programme.Ensure all work is conducted in compliance with the necessary regulatory standards including UKAS(for clinical samples) and GCLP (for clinical trials) also liaising with and supporting the Quality Officerin Quality related issues.Organisation Chart/Accountability
Please refer to the job description and person specification for further information.
Person Specification
Education/Training/Qualifications
Essential
- A relevant BSc in science or NVQ L3 equivalent
- Evidence of Continuing Professional Development (CPD)
Work Experience
Essential
- Minimum of 5 years practical and appropriate theoretical knowledge of analytical techniques including liquid chromatography and mass spectrometry
- Minimum of 5 years practical experience in clinical or analytical laboratory
Desirable
- Knowledge of extraction techniques used on biological matrices
- Knowledge of Health and Safety legislation applicable to laboratories
- Experience of working to regulatory or accreditation standards
Knowledge/Skills/Abilities
Essential
- To be proficient in and perform laboratory techniques and analysis
- To be competent in using Laboratory LIMS and other IT systems used within the Department
- Good interpretative skills
- Able to maintain and demonstrate a thorough level of practical competence and willingness to undertake further training as required
- Good organisational skills
- Good interpersonal skills
Desirable
- Knowledge of Good Clinical Practice for Laboratories, the Medicines for Human Use (Clinical Trials) Regulations
Personal Qualities/Special Circumstances
Essential
- Good communication skills, both written and verbal
- Able to show initiative
Person Specification
Education/Training/Qualifications
Essential
- A relevant BSc in science or NVQ L3 equivalent
- Evidence of Continuing Professional Development (CPD)
Work Experience
Essential
- Minimum of 5 years practical and appropriate theoretical knowledge of analytical techniques including liquid chromatography and mass spectrometry
- Minimum of 5 years practical experience in clinical or analytical laboratory
Desirable
- Knowledge of extraction techniques used on biological matrices
- Knowledge of Health and Safety legislation applicable to laboratories
- Experience of working to regulatory or accreditation standards
Knowledge/Skills/Abilities
Essential
- To be proficient in and perform laboratory techniques and analysis
- To be competent in using Laboratory LIMS and other IT systems used within the Department
- Good interpretative skills
- Able to maintain and demonstrate a thorough level of practical competence and willingness to undertake further training as required
- Good organisational skills
- Good interpersonal skills
Desirable
- Knowledge of Good Clinical Practice for Laboratories, the Medicines for Human Use (Clinical Trials) Regulations
Personal Qualities/Special Circumstances
Essential
- Good communication skills, both written and verbal
- Able to show initiative
Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the UK Visas and Immigration website (Opens in a new tab).
From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab).
Additional information
Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the UK Visas and Immigration website (Opens in a new tab).
From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab).
