Leeds Teaching Hospitals

Service Lead (Rare Disease) (XR08)

Information:

This job is now closed

Job summary

Permanent B8a Position

Lead Scientist: Core Rare Disease

37.5 hours per week, full time (five days out of six, including enhancements for weekend working)

Join us to make a meaningful difference to patients lives

If your passion is Genomics and you want to be at the forefront of improving outcomes for patients, then theres no better place to be.

LTHT is one of the largest and busiest acute hospital trusts in the UK. Last year, we treated more than 1.7 million patients and the Trust employs more than 21,000 staff.

Our care and clinical expertise is delivered from seven hospitals on five sites, and they are all joined by our vision to be the best for specialist and integrated care. We play an important role in the training and education of medical, nursing and dental students, and we are a centre for world class research, innovation and pioneeringnew treatments.

At LTHT, were committed to being the best place to work. Where you are empowered to push the boundaries of science and help drive continuous improvements in our service. We are committed to personal development and ensure that every individual has the opportunity to grow towards more senior roles. Theres no better place to make a difference to patients and their families.

Main duties of the job

We are currently recruiting for dedicated individuals to join our Rare Disease team as a Lead Scientist at St Jamess University Hospital. The successful candidate will manage an area of the Core Rare Disease service, overseeing all analytical work in this area with line management responsibility. We are looking for HCPC registered candidates with strong scientific experience in delivering a Genomics Rare Disease service.

The role responsibilities include:

Working closely with the NEY GLH Lead Scientist to ensure NEY GLH is at the forefront of National Genomic Testing Service and is underpinned by all appropriate structures (scientific, educational, quality and managerial) to maintain that position.

Under the professional supervision of the Lead Scientist, develop specific areas of highly specialist expertise and responsibility in clinical areas and provide significant clinical liaison. Rotation may be required to support organisational need.

Under the managerial supervision of the local Deputy for Rare Disease, develop areas of highly specialist expertise and responsibility in managerial areas.

To participate in some aspects of the management process within the laboratory, including some aspects of human resource management.

Providing advice to consultants and other service users

Making contributions to shape national best-practice

About us

Our 140-strong workforce provides the Leeds Central Laboratory for the NEY Genomic Laboratory Hub. The NEY GLH serves around 9 million patients regionally and brings together genomic expertise across NHS Trusts in Leeds, Newcastle and Sheffield. We also provide highly specialised tests for inherited cancers for the wider NHS.

The Leeds Central Laboratory is responsible for delivering the high throughput Next Generation Sequencing facility for the GLH, based around NovaSeq, NextSeq 550DX and Genexus platforms with associated technical and bioinformatics support to deliver an efficient service, in addition to a broad spectrum of equipment and technologies to support a full genomic laboratory.

Over £4m has been invested in new and cutting-edge equipment in the last four years.

Leeds Teaching Hospitals is committed to our process of redeploying 'at risk' members of our existing workforce to new roles. As such, all our job adverts are subject to this policy and we reserve the right to close, delay or remove adverts while this process is completed. If you do experience a delay in the shortlisting stage of the recruitment cycle, please bear with us while this process is completed, and contact the named contact if you have any questions.

Details

Date posted

06 February 2024

Pay scheme

Agenda for change

Band

Band 8a

Salary

£50,952 to £57,349 a year

Contract

Permanent

Working pattern

Full-time

Reference number

C9298-PATH-284

Job locations

St. James's University Hospital

Beckett Street

Leeds

LS9 7TF


Job description

Job responsibilities

JOB PURPOSE/SUMMARY

Work closely with the Y&NE GLH Lead Scientist(s) to ensure Y&NE GLH is at the forefront of National Genomic Testing Service and is underpinned by all appropriate structures (scientific, educational, quality and managerial) to maintain that position.

Under the professional supervision of the Lead Scientist, develop specific areas of highly specialist expertise and responsibility in clinical areas and provide significant clinical liaison. Rotation may be required to support organisational need.

Under the managerial supervision of the local Deputy for Oncology or Rare Disease, develop areas of highly specialist expertise and responsibility in managerial areas.

To participate in some aspects of the management process within the laboratory, including some aspects of human resource management.

Background

The reconfiguration of Genetic Laboratory service provision in England is supporting the creation of a world class resource in the use of genomics and genetic technologies within the NHS. It is based around the consolidation of services in to a network of Genomic Laboratory Hubs (GLHs) to create a genomic laboratory service infrastructure for the NHS in England.

Y&NE GLH comprises of a partnership arrangement between several organisations (Leeds Teaching Hospitals Trust, Sheffield Childrens Hospital FT, Newcastle Upon Tyne Hospitals FT and Sheffield Teaching Hospitals FT).

Key responsibilities of Y&NE GLH:

Consolidate services to deliver significant efficiencies

Operate within a national testing network

Operate a coherent informatics infrastructure

Sample collection, processing and logistics

Technical and analytical platforms

Bioinformatics, annotation and validation

Clinical interpretation, reporting and returning of results

Quality management and assurance of both processes and data

Plan & develop workforce for now and the future

Organisational governance and partnership arrangements

Promotion of research and innovation

Y&NE GLH will work across defined geographies to:

Work with other GLHs to form a national network of genomic laboratories providing a coordinated national genomic laboratory service, which will be part of the planned NHS Genomic Medicine Service.

Participate in regular meetings convened by NHS Englands Genomic Unit as part of the national network.

Deliver genomic testing, as outlined in the National Genomic Test Directory.

Provide the genomic testing service for national specialist testing within prescribed GLHs of the national network, and will work with the relevant clinicians and genomic MDTs.

Be responsible for establishing and maintaining local networks of any subcontracted laboratories and designated providers for cancer genomic testing providing a coordinated and comprehensive service to deliver standardised outcomes, ongoing consolidation, quality improvement, and adoption of new technologies under a suitable operating infrastructure and partnership agreement.

Consolidate the existing specialist genetic laboratories into state of the art, high throughput, high quality and standardised laboratories through the delivery of the majority of genomic tests running through a single laboratory based in Leeds.

Operate enhanced working practices to ensure genomic testing services are available to support the delivery of seven day services, and ensure that genomic technology platforms are fully optimised.

Be responsible for ensuring quality and the ongoing review of opportunities to further consolidate networked services, based on technological advances, the changing evidence base for genomic testing and the National Test Directory.

Be accountable to NHS Englands Genomics Unit within an agreed governance and operational framework that will oversee the test repertoire, co-ordinate the provision new national specialised testing services, monitor performance and finance.

Fulfil the membership criteria for UKGTN, UKAS ISO accreditation and any additional requirements as specified by the NHS England Genomics Unit.

PRINCIPAL DUTIES & AREAS OF RESPONSIBILITY

Clinical and Professional

To supervise and manage in all aspects and take responsibility for specific service areas provided by the laboratory including all clinical and developmental aspects, liaison with clinicians and reporting.

To demonstrate and apply a thorough understanding of the scientific principles involved in the delivery of the service including troubleshooting, where appropriate, of existing assays.

To correctly interpret and report the results of tests including those carried out by other members of staff. This can include complex statistical analysis, probability calculations to provide a risk estimate, the accurate clinical interpretation of abnormal results and use of specialised interpretive software.

To be responsible for the accuracy, timeliness and appropriateness of a variety of routine and non-routine highly specialist genetic tests.

To be personally responsible for the time management of multiple tasks as described in the job description and be able to respond to changing requirements.

To ensure that the service is effective and current by regular literature review.

In consultation with and under the overall supervision of the Head of Laboratory and their Deputy, to liaise with all clinical disciplines and laboratory departments in relation to the services at a local, regional and national level to ensure that the service is maintained and developed appropriately.

To participate in policy development in area of specialisation at a national level.

To implement national policies regarding area of specialisation within the department and advise senior management where they impact on the department.

To attend appropriate multidisciplinary team meetings on behalf of the department to give professional opinion on clinical cases.

To supervise the participation in external quality control schemes for the service ensuring that the results are provided in a timely and appropriate manner.

To be responsible for the comprehensive auditing of services provided, ensuring that all performance targets are monitored.

To contribute to the Health & Safety assessment of all processes within the group.

To check and countersign reports for a wide range of other services. Checking will include the accuracy and interpretation of results, the accuracy and validity of statistical or risk calculations, and the information and wording of the report.

To operate a flexible work practice outside normal working hours, this enables the efficient delivery of pre-natal, predictive or urgent testing.

To abide by the confidentiality policy, taking into account the sensitive and possible emotional nature of clinical referrals.

To maintain and update existing laboratory databases of clinical referrals, results and reports.

Managerial

To supervise and manage these services to national standards, providing appropriate advice and support to other Clinical Scientists/Healthcare Scientist and Practitioners/Genetic technologists where needed.

To manage and supervise the staff allocated to the above service(s) in all aspects of service provision.

To provide managerial and reporting cover across the department where competent.

To advise the management as to the strategic importance of any development for these services with regard to the commissioning process.

Participate in the recruitment and selection process of staff for these services.

Conduct staff reviews and personal development planning for these services.

Teaching, Research and Service Development

To participate in the training programme of the department.

Provide training for both clinical services and managerial functions where appropriate.

Participate in the development and validation of new tests of clinical diagnostic and prognostic importance within the section in a co-ordinated, cost-effective and timely manner.

Participate in the income generation of the department including scoping and developing new income generating services in a cost effective and competitive manner.

Patient/Customer Care

Responsible for the provision of clinical technical services.

Policy and Service Development

Work closely with and deputises for the Y&NE GLH Lead Scientist to ensure Y&NE GLH is at the forefront of National Genomic Testing Service and is underpinned by all appropriate structures (scientific, educational, quality and managerial) to maintain that position.

FINANCIAL & PHYSICAL RESOURCES

Human Resources

Responsible for the education and training.

Ensure systems are in place for all aspects in relation to the management, education and development of staff.

Promote and facilitate professional development of scientific and technical staff.

Information Resources

Responsible for the operation of information systems within the Y&NE GLH service.

Research and Development

Initiate, direct and undertake regular research and innovation activity.

Freedom to Act

Responsible for establishing the way in which general health and organisational policies are interpreted.

Participate in and drive research activity within the field in collaboration with clinicians and other scientists, including grant application and publication.

Present the results of service development at local, national and international meetings.

Undergo relevant training and professional development including attendance at relevant national and international meetings, to ensure the continuing development and improvement of the service.

The post holder will participate in an annual Personal Development Review process as well as all necessary mandatory training.

Job description

Job responsibilities

JOB PURPOSE/SUMMARY

Work closely with the Y&NE GLH Lead Scientist(s) to ensure Y&NE GLH is at the forefront of National Genomic Testing Service and is underpinned by all appropriate structures (scientific, educational, quality and managerial) to maintain that position.

Under the professional supervision of the Lead Scientist, develop specific areas of highly specialist expertise and responsibility in clinical areas and provide significant clinical liaison. Rotation may be required to support organisational need.

Under the managerial supervision of the local Deputy for Oncology or Rare Disease, develop areas of highly specialist expertise and responsibility in managerial areas.

To participate in some aspects of the management process within the laboratory, including some aspects of human resource management.

Background

The reconfiguration of Genetic Laboratory service provision in England is supporting the creation of a world class resource in the use of genomics and genetic technologies within the NHS. It is based around the consolidation of services in to a network of Genomic Laboratory Hubs (GLHs) to create a genomic laboratory service infrastructure for the NHS in England.

Y&NE GLH comprises of a partnership arrangement between several organisations (Leeds Teaching Hospitals Trust, Sheffield Childrens Hospital FT, Newcastle Upon Tyne Hospitals FT and Sheffield Teaching Hospitals FT).

Key responsibilities of Y&NE GLH:

Consolidate services to deliver significant efficiencies

Operate within a national testing network

Operate a coherent informatics infrastructure

Sample collection, processing and logistics

Technical and analytical platforms

Bioinformatics, annotation and validation

Clinical interpretation, reporting and returning of results

Quality management and assurance of both processes and data

Plan & develop workforce for now and the future

Organisational governance and partnership arrangements

Promotion of research and innovation

Y&NE GLH will work across defined geographies to:

Work with other GLHs to form a national network of genomic laboratories providing a coordinated national genomic laboratory service, which will be part of the planned NHS Genomic Medicine Service.

Participate in regular meetings convened by NHS Englands Genomic Unit as part of the national network.

Deliver genomic testing, as outlined in the National Genomic Test Directory.

Provide the genomic testing service for national specialist testing within prescribed GLHs of the national network, and will work with the relevant clinicians and genomic MDTs.

Be responsible for establishing and maintaining local networks of any subcontracted laboratories and designated providers for cancer genomic testing providing a coordinated and comprehensive service to deliver standardised outcomes, ongoing consolidation, quality improvement, and adoption of new technologies under a suitable operating infrastructure and partnership agreement.

Consolidate the existing specialist genetic laboratories into state of the art, high throughput, high quality and standardised laboratories through the delivery of the majority of genomic tests running through a single laboratory based in Leeds.

Operate enhanced working practices to ensure genomic testing services are available to support the delivery of seven day services, and ensure that genomic technology platforms are fully optimised.

Be responsible for ensuring quality and the ongoing review of opportunities to further consolidate networked services, based on technological advances, the changing evidence base for genomic testing and the National Test Directory.

Be accountable to NHS Englands Genomics Unit within an agreed governance and operational framework that will oversee the test repertoire, co-ordinate the provision new national specialised testing services, monitor performance and finance.

Fulfil the membership criteria for UKGTN, UKAS ISO accreditation and any additional requirements as specified by the NHS England Genomics Unit.

PRINCIPAL DUTIES & AREAS OF RESPONSIBILITY

Clinical and Professional

To supervise and manage in all aspects and take responsibility for specific service areas provided by the laboratory including all clinical and developmental aspects, liaison with clinicians and reporting.

To demonstrate and apply a thorough understanding of the scientific principles involved in the delivery of the service including troubleshooting, where appropriate, of existing assays.

To correctly interpret and report the results of tests including those carried out by other members of staff. This can include complex statistical analysis, probability calculations to provide a risk estimate, the accurate clinical interpretation of abnormal results and use of specialised interpretive software.

To be responsible for the accuracy, timeliness and appropriateness of a variety of routine and non-routine highly specialist genetic tests.

To be personally responsible for the time management of multiple tasks as described in the job description and be able to respond to changing requirements.

To ensure that the service is effective and current by regular literature review.

In consultation with and under the overall supervision of the Head of Laboratory and their Deputy, to liaise with all clinical disciplines and laboratory departments in relation to the services at a local, regional and national level to ensure that the service is maintained and developed appropriately.

To participate in policy development in area of specialisation at a national level.

To implement national policies regarding area of specialisation within the department and advise senior management where they impact on the department.

To attend appropriate multidisciplinary team meetings on behalf of the department to give professional opinion on clinical cases.

To supervise the participation in external quality control schemes for the service ensuring that the results are provided in a timely and appropriate manner.

To be responsible for the comprehensive auditing of services provided, ensuring that all performance targets are monitored.

To contribute to the Health & Safety assessment of all processes within the group.

To check and countersign reports for a wide range of other services. Checking will include the accuracy and interpretation of results, the accuracy and validity of statistical or risk calculations, and the information and wording of the report.

To operate a flexible work practice outside normal working hours, this enables the efficient delivery of pre-natal, predictive or urgent testing.

To abide by the confidentiality policy, taking into account the sensitive and possible emotional nature of clinical referrals.

To maintain and update existing laboratory databases of clinical referrals, results and reports.

Managerial

To supervise and manage these services to national standards, providing appropriate advice and support to other Clinical Scientists/Healthcare Scientist and Practitioners/Genetic technologists where needed.

To manage and supervise the staff allocated to the above service(s) in all aspects of service provision.

To provide managerial and reporting cover across the department where competent.

To advise the management as to the strategic importance of any development for these services with regard to the commissioning process.

Participate in the recruitment and selection process of staff for these services.

Conduct staff reviews and personal development planning for these services.

Teaching, Research and Service Development

To participate in the training programme of the department.

Provide training for both clinical services and managerial functions where appropriate.

Participate in the development and validation of new tests of clinical diagnostic and prognostic importance within the section in a co-ordinated, cost-effective and timely manner.

Participate in the income generation of the department including scoping and developing new income generating services in a cost effective and competitive manner.

Patient/Customer Care

Responsible for the provision of clinical technical services.

Policy and Service Development

Work closely with and deputises for the Y&NE GLH Lead Scientist to ensure Y&NE GLH is at the forefront of National Genomic Testing Service and is underpinned by all appropriate structures (scientific, educational, quality and managerial) to maintain that position.

FINANCIAL & PHYSICAL RESOURCES

Human Resources

Responsible for the education and training.

Ensure systems are in place for all aspects in relation to the management, education and development of staff.

Promote and facilitate professional development of scientific and technical staff.

Information Resources

Responsible for the operation of information systems within the Y&NE GLH service.

Research and Development

Initiate, direct and undertake regular research and innovation activity.

Freedom to Act

Responsible for establishing the way in which general health and organisational policies are interpreted.

Participate in and drive research activity within the field in collaboration with clinicians and other scientists, including grant application and publication.

Present the results of service development at local, national and international meetings.

Undergo relevant training and professional development including attendance at relevant national and international meetings, to ensure the continuing development and improvement of the service.

The post holder will participate in an annual Personal Development Review process as well as all necessary mandatory training.

Person Specification

Qualifications

Essential

  • Degree level education (or equivalent), plus further specialist training, experience, research or study to Masters degree level or equivalent.
  • Registered in appropriate scheme for Healthcare Scientist
  • Fellowship of the Royal College of Pathologists Part 1(FRCPath part 1) or equivalent experience

Desirable

  • Research experience as evidenced by publication
  • Fellowship of the Royal College of Pathologists (FRCPath)
  • A relevant higher degree such as a PhD in an appropriate subject

Experience

Essential

  • Demonstrable ability to manage groups of services, including staff
  • Ability to train and develop staff in clinical science
  • Use of scientific equipment
  • Good manual dexterity and hand/eye coordination to make fine adjustments to delicate instrumentation
  • Experience in Genetics over a wide range of services with substantial experience of service planning, development and delivery
  • Management experience

Skills & behaviours

Essential

  • Broad practical and theoretical knowledge of Human Genetics with some areas of highly specialist skills and detailed knowledge
  • Knowledge of Health and Safety and Quality Management in a laboratory environment particularly audit, clinical audit and audit processes
  • Excellent skills in the interpretation and reporting of highly complex DNA analysis and/or highly complex chromosome abnormalities
  • Represent Y&NE GLH at Operational Working Group as and when required
  • Workforce planning to ensure sufficient staffing at the right skill level to deliver the service
  • Manage activity to ensure Genomic Tests are interpreted and reported in accordance with national guidance and the Turnaround Times
  • Ensure Y&NE GLH has, or has access to appropriate technologies with sufficient capacity to meet service needs
  • Skills for manipulating specimens
  • Excellent organisational skills including meticulous record keeping
  • Good computer skills and familiarity with data analysis packages

Desirable

  • Standard keyboard skills
Person Specification

Qualifications

Essential

  • Degree level education (or equivalent), plus further specialist training, experience, research or study to Masters degree level or equivalent.
  • Registered in appropriate scheme for Healthcare Scientist
  • Fellowship of the Royal College of Pathologists Part 1(FRCPath part 1) or equivalent experience

Desirable

  • Research experience as evidenced by publication
  • Fellowship of the Royal College of Pathologists (FRCPath)
  • A relevant higher degree such as a PhD in an appropriate subject

Experience

Essential

  • Demonstrable ability to manage groups of services, including staff
  • Ability to train and develop staff in clinical science
  • Use of scientific equipment
  • Good manual dexterity and hand/eye coordination to make fine adjustments to delicate instrumentation
  • Experience in Genetics over a wide range of services with substantial experience of service planning, development and delivery
  • Management experience

Skills & behaviours

Essential

  • Broad practical and theoretical knowledge of Human Genetics with some areas of highly specialist skills and detailed knowledge
  • Knowledge of Health and Safety and Quality Management in a laboratory environment particularly audit, clinical audit and audit processes
  • Excellent skills in the interpretation and reporting of highly complex DNA analysis and/or highly complex chromosome abnormalities
  • Represent Y&NE GLH at Operational Working Group as and when required
  • Workforce planning to ensure sufficient staffing at the right skill level to deliver the service
  • Manage activity to ensure Genomic Tests are interpreted and reported in accordance with national guidance and the Turnaround Times
  • Ensure Y&NE GLH has, or has access to appropriate technologies with sufficient capacity to meet service needs
  • Skills for manipulating specimens
  • Excellent organisational skills including meticulous record keeping
  • Good computer skills and familiarity with data analysis packages

Desirable

  • Standard keyboard skills

Disclosure and Barring Service Check

This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.

Employer details

Employer name

Leeds Teaching Hospitals

Address

St. James's University Hospital

Beckett Street

Leeds

LS9 7TF


Employer's website

https://www.leedsth.nhs.uk/ (Opens in a new tab)


Employer details

Employer name

Leeds Teaching Hospitals

Address

St. James's University Hospital

Beckett Street

Leeds

LS9 7TF


Employer's website

https://www.leedsth.nhs.uk/ (Opens in a new tab)


Employer contact details

For questions about the job, contact:

Deputy Head of Laboratory

Andrea Coates

andrea.coates1@nhs.net

Details

Date posted

06 February 2024

Pay scheme

Agenda for change

Band

Band 8a

Salary

£50,952 to £57,349 a year

Contract

Permanent

Working pattern

Full-time

Reference number

C9298-PATH-284

Job locations

St. James's University Hospital

Beckett Street

Leeds

LS9 7TF


Supporting documents

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