Job summary
The postholder will contribute to the development, validation and implementation of Artificial Intelligence and Machine Learning methodologies to enhance genomic data analysis and interpretation in a clinical setting. Working within the Translational Research and Bioinformatics team, the Research Bioinformatician will support translational research, optimise data pipelines for high-throughput sequencing, and integrate AI/ML approaches into clinical workflows. The role involves close collaboration with clinicians, scientists, data engineers and external partners to ensure research outputs are robust, reproducible and clinically relevant.
In addition, the postholder will design and develop web portals for data visualisation, support scientists with NGS data analysis and interpretation, and manage data storage, backup and user support. They will also contribute to staff training, documentation and SOPs, ensuring compliance with legal and ethical standards for handling and transmitting genetic and sensitive patient data
Main duties of the job
The main objective of the post holder is to provide expert bioinformatics knowledge and support for the provision and development of next generation sequencing (NGS) data analysis in Clinical Genomics both for diagnostic and R&D applications. They will contribute to the development of analysis pipelines and state of the art web portal necessary to provide an efficient and high quality clinical genomics service for cancer patients. Responsibilities of the post holder will include designing, implementing and maintaining NGS data analysis pipelines for a range of applications including custom enrichment panels, whole exome sequencing, gene expression profiling as well as genome-wide methylation analysis.In addition, the post holder will also involved in designing web portal for data visulisation and supporting Clinical Scientists and research scientist to analyse and interpret NGS report. Moreover, the post holder will be responsible for storage and backup of NGS data, user support, delivering staff training, writing standard operating procedures and other documents as well as ensuring that the department complies with legal and professional requirements in regards to storage and transmission of patient's genetic and sensitive data.
About us
The Royal Marsden NHS Foundation Trust is a world-leading cancer centre. Our role is to offer our patients the best cancer care available anywhere in the world, and to continue to make a global contribution to finding better ways of diagnosing and treating cancer. We employ over 4,500 staff in a diverse range of careers including nursing, medical, science, radiography, pharmacy, occupational therapy, finance and administrative services. We have two hospitals - one in Chelsea, London, and one in Sutton, Surrey - as well as a Medical Daycare Unit in Kingston Hospital.
At The Royal Marsden, we deal with cancer every day, so we understand how valuable life is. When people entrust their lives to us, they have the right to demand the very best. That's why the pursuit of excellence lies at the heart of everything we do.
At the heart of the hospital is our dedicated team. We offer a stimulating and dynamic working environment, a wide range of staff benefits, learning and development opportunities and clear career pathways. There are opportunities to work flexibly across a range of areas and specialities and we welcome flexible working requests from point of hire to support employees work life balance. We are looking for employees who aspire to excellence, share our values and can play a crucial role in our on-going achievements.
Job description
Job responsibilities
For further information please refer to the job description and personal specification
To develop and maintain a secure web portal for the NGS data analysis and sharing of clinical data.
Maintain internal databases, linked to the main public genome databases and North Thames Genomic Laboratory Hub (NT-GLH) central database
To organise, store and backup data in a timely manner.
To operate pipelines for the processing and analysis of raw data from high throughput sequencing (next generation sequencing) including calling of variants, translocations, amplification, deletions and other clinically relevant genomic alterations.
Job description
Job responsibilities
For further information please refer to the job description and personal specification
To develop and maintain a secure web portal for the NGS data analysis and sharing of clinical data.
Maintain internal databases, linked to the main public genome databases and North Thames Genomic Laboratory Hub (NT-GLH) central database
To organise, store and backup data in a timely manner.
To operate pipelines for the processing and analysis of raw data from high throughput sequencing (next generation sequencing) including calling of variants, translocations, amplification, deletions and other clinically relevant genomic alterations.
Person Specification
Skills and Abilities
Essential
- Educational qualification in mathematics
Personal Qualities
Essential
- Evidence of personal development
- Self confident, contributes to laboratory meetings
- Able to work unsupervised
- Flexible approach to work, decision maker
Specific Experience
Essential
- BSc in biological sciences / bioinformatics / computational biology
- MSc in bioinformatics/computational biology
- HCPC-Registered Clinical Bioinformatician or working towards registration
- Good knowledge of open source bioinformatics tools and genomic databases
- Experience of UNIX/LINUX operating systems to an advanced level
- Experience of high performance computing systems and parallelising jobs
- Experience of working in DNA-seq NGS
- Experience in programming using scripting languages, e.g. Perl, Python, R or Java
- Experience of working in cancer genetics
- Experience working in bioinformatics/computational biology
- Proven ability to organise daily work plans and schedules
- Ability to automate processes and analysis
Desirable
- PhD in bioinformatics/computational biology or equivalent experience
- Experience of working in other NGS applications i.e. RNA-seq
- Experience with development and maintenance of a web portal
- Able to perform advanced training and ensuring compliance with professional standards
- Knowledge of Next Generation Sequencing analysis and data storage in Cloud
Skills and Abilities
Essential
- Good interpersonal skills
- Ability to express and communicate ideas, concepts and findings in all circumstances including email and telephone
- Good judgement, analytical, perceptive, eye for detail
- Able to take specific responsibilities in an area of defined specialist knowledge
- Able to deal with database/systems trouble shooting
Desirable
- Awareness of organisational and logistical issues
Personal Qualities
Essential
- Enthusiasm for job and profession
- Commitment to team working
Specific Experience
Essential
- Ability to automate processes and analysis
Desirable
- Ability to perform complex data audits
- Knowledge and understanding of ISO15189 standard
- General understanding of all aspects of quality management
Clinical Responsibility
Essential
- Understanding of relationship between laboratory investigations, data analysis and clinical practice
- Awareness of clinical significance of genetic findings and implications for patients
- Ability to extrapolate from basic information to consider additional investigations to perform
- Ability to review anomalous / unexpected findings and take further appropriate action
Desirable
- Ability to manage the bioinformatics workflow on a daily basis
Person Specification
Skills and Abilities
Essential
- Educational qualification in mathematics
Personal Qualities
Essential
- Evidence of personal development
- Self confident, contributes to laboratory meetings
- Able to work unsupervised
- Flexible approach to work, decision maker
Specific Experience
Essential
- BSc in biological sciences / bioinformatics / computational biology
- MSc in bioinformatics/computational biology
- HCPC-Registered Clinical Bioinformatician or working towards registration
- Good knowledge of open source bioinformatics tools and genomic databases
- Experience of UNIX/LINUX operating systems to an advanced level
- Experience of high performance computing systems and parallelising jobs
- Experience of working in DNA-seq NGS
- Experience in programming using scripting languages, e.g. Perl, Python, R or Java
- Experience of working in cancer genetics
- Experience working in bioinformatics/computational biology
- Proven ability to organise daily work plans and schedules
- Ability to automate processes and analysis
Desirable
- PhD in bioinformatics/computational biology or equivalent experience
- Experience of working in other NGS applications i.e. RNA-seq
- Experience with development and maintenance of a web portal
- Able to perform advanced training and ensuring compliance with professional standards
- Knowledge of Next Generation Sequencing analysis and data storage in Cloud
Skills and Abilities
Essential
- Good interpersonal skills
- Ability to express and communicate ideas, concepts and findings in all circumstances including email and telephone
- Good judgement, analytical, perceptive, eye for detail
- Able to take specific responsibilities in an area of defined specialist knowledge
- Able to deal with database/systems trouble shooting
Desirable
- Awareness of organisational and logistical issues
Personal Qualities
Essential
- Enthusiasm for job and profession
- Commitment to team working
Specific Experience
Essential
- Ability to automate processes and analysis
Desirable
- Ability to perform complex data audits
- Knowledge and understanding of ISO15189 standard
- General understanding of all aspects of quality management
Clinical Responsibility
Essential
- Understanding of relationship between laboratory investigations, data analysis and clinical practice
- Awareness of clinical significance of genetic findings and implications for patients
- Ability to extrapolate from basic information to consider additional investigations to perform
- Ability to review anomalous / unexpected findings and take further appropriate action
Desirable
- Ability to manage the bioinformatics workflow on a daily basis
Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
UK Registration
Applicants must have current UK professional registration. For further information please see
NHS Careers website (opens in a new window).
Additional information
Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
UK Registration
Applicants must have current UK professional registration. For further information please see
NHS Careers website (opens in a new window).
