Job summary
We are looking for an experienced research scientist to work in the Royal Marsden Clinical Genomics team, supporting clinical diagnostics and translational research projects. The post-holder will work with a highly experienced team of scientists to analyse and report samples mainly for a prostate cancer clinical study entitled "STAMPEDE". This project will run until 2029 and the successful candidate will be appointed on a 12-month fixed term contract in the first instance with potential extension for the lifetime of the project. The work will take place in the Clinical Genomics Translational Research Laboratory at The BRC Centre for Molecular Pathology at The Royal Marsden NHS FT and The Institute of Cancer Research in Sutton.
Main duties of the job
- Ensure that clinical trial requests are met according to agreed policies on availability of tests and priorities.
- Monitor pathway from sample receipt to reporting for STAMPEDE trial.
- Ensure that work is carried out in line with Standard Operating Procedures and Departmental policy.
About us
The Royal Marsden NHS Foundation Trust is a world-leading cancer centre. Our role is to offer our patients the best cancer care available anywhere in the world, and to continue to make a global contribution to finding better ways of diagnosing and treating cancer. We employ over 4,500 staff in a diverse range of careers including nursing, medical, science, radiography, pharmacy, occupational therapy, finance and administrative services. We have two hospitals - one in Chelsea, London, and one in Sutton, Surrey - as well as a Medical Daycare Unit in Kingston Hospital.
At The Royal Marsden, we deal with cancer every day, so we understand how valuable life is. When people entrust their lives to us, they have the right to demand the very best. That's why the pursuit of excellence lies at the heart of everything we do.
At the heart of the hospital is our dedicated team. We offer a stimulating and dynamic working environment, a wide range of staff benefits, learning and development opportunities and clear career pathways. There are opportunities to work flexibly across a range of areas and specialities and we welcome flexible working requests from point of hire to support employees work life balance. We are looking for employees who aspire to excellence, share our values and can play a crucial role in our on-going achievements.
Job description
Job responsibilities
For further information on this role, please see the attached detailed Job Description and Person Specification:
The post holder will contribute to service development and analysis, including the design and implementation of genomic protocols for personalised medicine using high throughput sequence analysis. They will implement DNA and RNA sequencing on both Illumina and Nanopore platforms, whole genome sequencing and circulating tumour DNA sequencing in a clinically-accredited laboratory to clinically specified turnaround times. The post holder will liaise with BRC researchers and their collaborators at local and national levels, clinical trials unit staff, clinicians, oncologists and histopathologists and will be responsible for delivering a high quality molecular diagnostic service supporting clinical trials and associated research projects across a wide range of cancers.
Job description
Job responsibilities
For further information on this role, please see the attached detailed Job Description and Person Specification:
The post holder will contribute to service development and analysis, including the design and implementation of genomic protocols for personalised medicine using high throughput sequence analysis. They will implement DNA and RNA sequencing on both Illumina and Nanopore platforms, whole genome sequencing and circulating tumour DNA sequencing in a clinically-accredited laboratory to clinically specified turnaround times. The post holder will liaise with BRC researchers and their collaborators at local and national levels, clinical trials unit staff, clinicians, oncologists and histopathologists and will be responsible for delivering a high quality molecular diagnostic service supporting clinical trials and associated research projects across a wide range of cancers.
Person Specification
Skills and Abilities
Essential
- Interpersonal and communication skills
- Ability to write clear and concise scientific reports
- Competent in using of Microsoft software or equivalent
- Ability to perform standard scientific calculations, data analysis and interpretation using complex genetics softwar
- Ability to troubleshoot laboratory and logistical problems
Personal Qualities
Essential
- Proven commitment to personal development and enthusiasm for the job
- Self-confident, contributes to laboratory meetings, committed to team working
- Flexible approach to work, ability to work independently
Specific Experience
Essential
- BSc in a scientific subject relevant to genomics
- Understanding and/or experience of SOPs
- Understanding and work experience in genetics/genomics
- Laboratory experience with DNA and RNA based methods
- Able to work to deadlines as well as organise daily work plans and schedules
Desirable
- MSc or PhD degree in a genetics/genomics related subject
- Knowledge of bioinformatic approaches for analysis of genomic data
- Proven ability to plan genomics workflows and experience of high throughput sequencing technologies
Clinical Responsibility
Essential
- Ability to review anomalous / unexpected findings and take further appropriate action
Desirable
- Ability to extrapolate from basic information to consider additional investigations to perform
Person Specification
Skills and Abilities
Essential
- Interpersonal and communication skills
- Ability to write clear and concise scientific reports
- Competent in using of Microsoft software or equivalent
- Ability to perform standard scientific calculations, data analysis and interpretation using complex genetics softwar
- Ability to troubleshoot laboratory and logistical problems
Personal Qualities
Essential
- Proven commitment to personal development and enthusiasm for the job
- Self-confident, contributes to laboratory meetings, committed to team working
- Flexible approach to work, ability to work independently
Specific Experience
Essential
- BSc in a scientific subject relevant to genomics
- Understanding and/or experience of SOPs
- Understanding and work experience in genetics/genomics
- Laboratory experience with DNA and RNA based methods
- Able to work to deadlines as well as organise daily work plans and schedules
Desirable
- MSc or PhD degree in a genetics/genomics related subject
- Knowledge of bioinformatic approaches for analysis of genomic data
- Proven ability to plan genomics workflows and experience of high throughput sequencing technologies
Clinical Responsibility
Essential
- Ability to review anomalous / unexpected findings and take further appropriate action
Desirable
- Ability to extrapolate from basic information to consider additional investigations to perform
Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
