Job summary
The postholder will be based at the ICR and The Royal Marsden, primarily in Chelsea. The post is a fully funded for a PhD. This is a translational research post and the candidate will be expected to register for a PhD at ICR. Clinical commitments will include weekly head and neck Research clinics. For trainees in clinical oncology there will be opportunities to perform radiotherapy planning to keep up their skills. The research will involve analysis of tissue and blood samples that have been collected from patients undergoing radical treatment (CRT) for HNSCC.
Main duties of the job
The post is primarily laboratory based at the ICR in Chelsea.
Lab duties involve- The required training will be provided but some lab experience will be desirable.
- Nucleic acid (DNA and RNA) extraction from formalin fixed tissue (FFPE), buffy coats and plasma using widely used kits.
- Library preparation for TCR and cHPV-DNA sequencing on the relevant platform.
- Software programming in R and python for bioinformatics analysis. Using bioinformatics tools such as BEDtools and SAMtools.
- Statistical analyses using parametric and non- parametric tests for comparison between groups, correlation coefficients and multivariate analyses.
Clinical Duties
One Out-patient clinic per week in the head and neck, primarily looking after patients on clinical trials of novel systemic therapies including immunotherapy.
The post-holder will develop the following experience during the tenure of the post:
DNA and RNA sequencing of patient samples.
Bioinformatic analyses of these.
Clinical Management of Head & Neck CancersPresentation, publication and peer review
About us
The Royal Marsden is recognised worldwide for the quality of its cancer services. The Trust's strategic aim is to achieve excellence in cancer treatment and diagnosis, through partnership and collaboration.
As a leading Cancer Centre, the Trust has close working relationships with many Cancer Units and other Cancer Centres. Predominantly the Trust's workload is from within the Southwest and West London Cancer Networks but the Trust is unique in having a high out-of-area referral rate for rare cancers, recurrent disease and clinical trials.
Job description
Job responsibilities
The post-holder will develop the following experience during the tenure of the post:
Clinical Management of Head & Neck Cancers Presentation, publication and peer review Audit and guideline development
The post-holder will develop his/her own area of expertise during the tenure of the post. The tenure of the post is expected to be for 12 months with a view to extend for a further 12-24 months. In order to maintain clinical experience, post-holder will be expected to attend out-patient clinics.
For further details / informal visits contact:
Carmel Keyzor, Clinical Research Operations Manager
Email: Carmel.Keyzor2@rmh.nhs.uk
Job description
Job responsibilities
The post-holder will develop the following experience during the tenure of the post:
Clinical Management of Head & Neck Cancers Presentation, publication and peer review Audit and guideline development
The post-holder will develop his/her own area of expertise during the tenure of the post. The tenure of the post is expected to be for 12 months with a view to extend for a further 12-24 months. In order to maintain clinical experience, post-holder will be expected to attend out-patient clinics.
For further details / informal visits contact:
Carmel Keyzor, Clinical Research Operations Manager
Email: Carmel.Keyzor2@rmh.nhs.uk
Person Specification
Education/Qualifications
Essential
- Eligible for full Registration with the GMC
Experience
Essential
- ST3 or above level of experience in full-time postgraduate training (or its equivalent gained on a parttime or flexible basis) at least one of which will be in a specialty training programme in a relevant specialty or as a fixed term specialty trainee in a relevant specialty; or shall have equivalent experience and competencies.
- Ability to work within a multidisciplinary team and manage junior doctors
- Appropriate knowledge base and ability to apply sound clinical judgement to problems; able to prioritise clinical need.
- Motivated to ensure the achievement of defined targets
- Is up to date and fit to practise safely
- Excellent numerical skills
Desirable
- Interest in head & Neck cancers.
- Research experience and data analysis skills.
- Wet lab experience
Skills/Abilities/Knowledge
Essential
- All applicants able to demonstrate skills in written and spoken English that are adequate to enable effective communication about medical topics with patients and colleagues
- Good communications skills, ability to work as part as a team, take initiative and make decisions.
Desirable
- Basic knowledge and interest in head & neck cancers
- Basic bioinformatics skills including coding in "R"
Person Specification
Education/Qualifications
Essential
- Eligible for full Registration with the GMC
Experience
Essential
- ST3 or above level of experience in full-time postgraduate training (or its equivalent gained on a parttime or flexible basis) at least one of which will be in a specialty training programme in a relevant specialty or as a fixed term specialty trainee in a relevant specialty; or shall have equivalent experience and competencies.
- Ability to work within a multidisciplinary team and manage junior doctors
- Appropriate knowledge base and ability to apply sound clinical judgement to problems; able to prioritise clinical need.
- Motivated to ensure the achievement of defined targets
- Is up to date and fit to practise safely
- Excellent numerical skills
Desirable
- Interest in head & Neck cancers.
- Research experience and data analysis skills.
- Wet lab experience
Skills/Abilities/Knowledge
Essential
- All applicants able to demonstrate skills in written and spoken English that are adequate to enable effective communication about medical topics with patients and colleagues
- Good communications skills, ability to work as part as a team, take initiative and make decisions.
Desirable
- Basic knowledge and interest in head & neck cancers
- Basic bioinformatics skills including coding in "R"
Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the UK Visas and Immigration website (Opens in a new tab).
From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab).
UK Registration
Applicants must have current UK professional registration. For further information please see
NHS Careers website (opens in a new window).
Additional information
Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the UK Visas and Immigration website (Opens in a new tab).
From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab).
UK Registration
Applicants must have current UK professional registration. For further information please see
NHS Careers website (opens in a new window).
