Job summary
We are seeking a skilled and enthusiastic bioinformatician funded by the NIHR Great Ormond Street Biomedical Research Centre and Great Ormond Street Children's Charity to join our team based in the North Thames Genomic Laboratory Hub at Great Ormond Street Hospital. Our team is delivering transformation in patient care by using circulating cell free DNA to develop new approaches to diagnosis and monitoring, developing pipelines for rapid, comprehensive diagnosis of paediatric conditions such as early onset epilepsy using whole genome sequencing and utilising long read sequencing technologies to transform clinical services.
If you are committed to contributing to a team delivering excellence in research in genetics and genomics and would like to gain experience in translational research this is definitely the post for you. This Band 7 post is available immediately for two years. You will be joining an enthusiastic, friendly, motivated multidisciplinary research team working closely with the Clinical Bioinformatics team. This is an ideal opportunity to seriously contribute to translating research into clinical practice for the benefit of patients. This post is suitable for research or postdoctoral bioinfomaticians wanting to explore the exciting area of translational research or for clinical Bioinformaticians who want to broaden their horizons with research experience.
Main duties of the job
- Assume responsibility alongside the lead Bioinformatician and Translational Scientist for the translational bioinformatics research work in the RD lab hub at Great Ormond Street NHS Foundation Trust, whilst working closely with the GOSH BRC, UCL Genomics and the cancer Hub at the Royal Marsden Hospital to ensure alignment and sharing of practices across the BRC and GLH
- To provide high end bioinformatics knowledge and support in the delivery of a reliable, competitive, efficient, cost effective and high-quality research and development programme that ultimately contributes to the diagnostic service
- To pro-actively propose and develop improvements and research methodologies
- To work closely with the Clinical Bioinformatics team and translational scientist team along with other GLHs as required to facilitate the translation of research to clinical service.
- To develop collaborative projects with fellow professionals from across the GLH and other national and international institutions as appropriate
- To publish service and research findings in high quality, peer-reviewed journals
- To establish and maintain excellent working relationships with professional colleagues within the BRC and it's Paediatric Excellence Initiative partners in Birmingham, UCL Genomics, NT GLH, other GLHs, and national and international collaborators
About us
GOSH is committed to recruiting the best person for the job, based solely on their ability and individual merit as measured against the criteria for the role; through a process that is fair, open, consistent and free from bias and discrimination.
We are committed to being a diverse and inclusive employer and foster a culture where all staff are valued, respected and acknowledged. All applicants will receive consideration for employment without regard to race, colour, national origin, religion, sexual orientation, gender, gender identity, age, disability status or length of time spent unemployed.
We particularly welcome applications from BAME communities, people with disabilities and/or long-term health conditions and LGBT+ community members.
We have policies and procedures in place to ensure that all applicants and employees are treated fairly and consistently. We are proud to be accredited as a Disability Confident Employer, a member of Business Disability Forum and a Stonewall Diversity Champion.
We have active and Executive supported BAME, LGBT+ and Allies, Disability and Long-Term Health Conditions and Women's staff networks. Staff networks are employee-led groups formed around interests, issues and a common bond or background. Staff network members create a positive and inclusive work environment at Great Ormond Street Hospital by actively contributing to the Trust's mission, values and efforts specific to inclusion. All of our staff networks are open to any employee.
Job description
Job responsibilities
The full job description provides an overview of the key tasks and responsibilities of the role, and the person specification outlines the qualifications, skills, experience, and knowledge required. For both documents please view the attachment.
Job description
Job responsibilities
The full job description provides an overview of the key tasks and responsibilities of the role, and the person specification outlines the qualifications, skills, experience, and knowledge required. For both documents please view the attachment.
Person Specification
GOSH Culture and Values
Essential
- Our Always values
- Knowledge and Understanding of diverse backgrounds and perspectives.
- Understanding of Diversity and Inclusion challenges in the workplace.
- Demonstrable contribution to advancing Equality, Diversity and Inclusion in the Workplace
- Able to work on site when required
Academic/Professional qualification/Training
Essential
- 1st or 2nd class honours degree in genetics or a relevant biological subject
Desirable
- PhD in Bioinformatics/Computational Biology
Experience/Knowledge
Essential
- Demonstrable experience of programming skills including a thorough knowledge of python scripting language
- Previous experience of bioinformatics and familiarity developing and maintaining NGS data pipelines
- Experience using workflow frameworks such as snakemake or nextflow
- Experience of software/algorithm development, testing, introduction, maintenance, and support
- Experience of UNIX/LINUX operating systems to an advanced level
- Experience with version control systems such as git or mercurial
- Experience of dealing with large data sets
- Experience of project management
- Knowledge and experience of Linux system administration
- Up to date knowledge of next generation sequencing and noninvasive prenatal diagnosis
- Knowledge of database design, development and administration including evaluating and understanding database schemas
Desirable
- Experience of programming in R
- Containerisation of pipelines / software with docker
- Knowledge and experience with cloud platforms e.g. AWS or Azure
- Up to date knowledge of the relevant scientific literature
- Experience developing web applications with Django web framework
Skills/Abilities
Essential
- Ability to communicate highly complex information in both verbal and written formats
- Positive, "can do" attitude to work
- Evidence of excellent inter-personal communication skills
- Excellent organisational and time management skills with ability to prioritise tasks effectively
- Excellent IT, data management and data analysis knowledge and skills
- Ability to develop and maintain excellent communication and working relationships
- Proactive and innovative approach to service improvement and delivery
- Ability to multitask and work on more than one project at a time
- Ability to multitask and work on more than one project at a time
- Ability to collate, write, publish and present research findings
- Ability to work independently under the direction of senior staff
- Ability to pay attention to detail and maintain accurate records
Person Specification
GOSH Culture and Values
Essential
- Our Always values
- Knowledge and Understanding of diverse backgrounds and perspectives.
- Understanding of Diversity and Inclusion challenges in the workplace.
- Demonstrable contribution to advancing Equality, Diversity and Inclusion in the Workplace
- Able to work on site when required
Academic/Professional qualification/Training
Essential
- 1st or 2nd class honours degree in genetics or a relevant biological subject
Desirable
- PhD in Bioinformatics/Computational Biology
Experience/Knowledge
Essential
- Demonstrable experience of programming skills including a thorough knowledge of python scripting language
- Previous experience of bioinformatics and familiarity developing and maintaining NGS data pipelines
- Experience using workflow frameworks such as snakemake or nextflow
- Experience of software/algorithm development, testing, introduction, maintenance, and support
- Experience of UNIX/LINUX operating systems to an advanced level
- Experience with version control systems such as git or mercurial
- Experience of dealing with large data sets
- Experience of project management
- Knowledge and experience of Linux system administration
- Up to date knowledge of next generation sequencing and noninvasive prenatal diagnosis
- Knowledge of database design, development and administration including evaluating and understanding database schemas
Desirable
- Experience of programming in R
- Containerisation of pipelines / software with docker
- Knowledge and experience with cloud platforms e.g. AWS or Azure
- Up to date knowledge of the relevant scientific literature
- Experience developing web applications with Django web framework
Skills/Abilities
Essential
- Ability to communicate highly complex information in both verbal and written formats
- Positive, "can do" attitude to work
- Evidence of excellent inter-personal communication skills
- Excellent organisational and time management skills with ability to prioritise tasks effectively
- Excellent IT, data management and data analysis knowledge and skills
- Ability to develop and maintain excellent communication and working relationships
- Proactive and innovative approach to service improvement and delivery
- Ability to multitask and work on more than one project at a time
- Ability to multitask and work on more than one project at a time
- Ability to collate, write, publish and present research findings
- Ability to work independently under the direction of senior staff
- Ability to pay attention to detail and maintain accurate records
Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the UK Visas and Immigration website (Opens in a new tab).
From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab).
UK Registration
Applicants must have current UK professional registration. For further information please see
NHS Careers website (opens in a new window).
Additional information
Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the UK Visas and Immigration website (Opens in a new tab).
From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab).
UK Registration
Applicants must have current UK professional registration. For further information please see
NHS Careers website (opens in a new window).
Employer details
Employer name
Great Ormond Street Hospital for Children NHS Foundation Trust
Address
Great Ormond Street Hospital for Children NHS Trust Great Ormond Street
Great Ormond Street Hospital
LondonLondon
WC1N 3JH
Employer's website
https://www.gosh.nhs.uk/ (Opens in a new tab)
