Job summary
We currently have an exciting opportunity for a Band 7 researcher to join our Hepatocyte Biology and Transplantation Group at the Mowat Labs at King's College Hospital. Housed within the Institute of Liver Studies, MowatLabs, brings together a critical mass of clinicians, researchers, nurses, intensivists, surgeons and transplant specialists, in a collaborative research environment, strengthening the quality and output of research predominately for children's liver disease, but also for research into children's respiratory medicine, gastroenterology, and sickle cell disease.
Main duties of the job
The role of this new position of Senior Liver Cell Scientist will be to develop basic and translational research on 1) new advanced therapy medicinal products (ATMPs) for paediatric liver disease using 3D bioprinting technology and 2) new extracellular matrix biomaterials for 3D bioprinting applications.
The post holder will also participate in the GMP production of primary human hepatocytes in the Cell Therapy Unit, after appropriate training.
About us
King's College Hospital NHS Foundation Trust is one of the UK's largest and busiest teaching Trusts with a turnover of c£1 billion, 1.5 million patient contacts a year and more than 15,000 staff based across South East London. The Trust provides a full range of local and specialist services across its five sites. The trust-wide strategy of Strong Roots, Global Reach is our Vision to be BOLD, Brilliant people, Outstanding care, Leaders in Research, Innovation and Education, Diversity, Equality and Inclusion at the heart of everything we do. By being person-centred, digitally-enabled, and focused on sustainability, we aim to take Team King's to another level.
We are at a pivotal point in our history and we require individuals who are ready to join a highly professional team and make a real, lasting difference to our patients and our people.
King's is committed to delivering Sustainable Healthcare for All via our Green Plan. In line with national Greener NHS ambitions, we have set net zero carbon targets of 2040 for our NHS Carbon Footprint and 2045 for our NHS Carbon Footprint Plus. Everyone's contribution is required in order to meet the goals set out in our Green Plan and we encourage all staff to work responsibly, minimising their contributions to the Trust's carbon emissions, waste and pollution wherever possible.
Job description
Job responsibilities
The post holder is a member of a multidisciplinary team developing the use of hepatocyte transplantation, and related cell-based therapies, in children with liver disease. They will be based at two locations the Institute of Liver Studies laboratories and the Cell Isolation Unit.
The post is split between research (80-90%) and GMP cell isolation work (10-20%).
The post holder is responsible for the development of new extracellular matrix-based biomaterials for 3D bioprinting applications and will be working within the 3D bioprinting team which is investigating new advanced therapy medicinal products (ATMPs) for paediatric liver disease using 3D bioprinting technology. They also perform cell isolations aiming to produce high quality cells for clinical administration.
The post holder should have a PhD in Biomedical Engineering/Cell Biology or equivalent experience with tissue engineering or relevant area of engineering and / or scientific research. Experience working with biomaterials and/or ECM proteins is desirable.
The post holder will conduct independent research into ECM-based bioinks for liver tissue engineering applications; collaborate closely with another senior researcher and a PhD student as part of the bioprinting sub-group within the lab; present their work in weekly research meeting; provide support and advice to students within the group; develop figures, search scientific literature, assist in writing manuscripts, submit abstracts, and present data at local and international meetings; participate in the isolation of liver cells under good manufacturing practices (GMP); Attend educational sessions, such as relevant lectures and journal clubs.
Job description
Job responsibilities
The post holder is a member of a multidisciplinary team developing the use of hepatocyte transplantation, and related cell-based therapies, in children with liver disease. They will be based at two locations the Institute of Liver Studies laboratories and the Cell Isolation Unit.
The post is split between research (80-90%) and GMP cell isolation work (10-20%).
The post holder is responsible for the development of new extracellular matrix-based biomaterials for 3D bioprinting applications and will be working within the 3D bioprinting team which is investigating new advanced therapy medicinal products (ATMPs) for paediatric liver disease using 3D bioprinting technology. They also perform cell isolations aiming to produce high quality cells for clinical administration.
The post holder should have a PhD in Biomedical Engineering/Cell Biology or equivalent experience with tissue engineering or relevant area of engineering and / or scientific research. Experience working with biomaterials and/or ECM proteins is desirable.
The post holder will conduct independent research into ECM-based bioinks for liver tissue engineering applications; collaborate closely with another senior researcher and a PhD student as part of the bioprinting sub-group within the lab; present their work in weekly research meeting; provide support and advice to students within the group; develop figures, search scientific literature, assist in writing manuscripts, submit abstracts, and present data at local and international meetings; participate in the isolation of liver cells under good manufacturing practices (GMP); Attend educational sessions, such as relevant lectures and journal clubs.
Person Specification
qualification
Essential
- Relevant PhD in appropriate Biomedical Engineering/Life Sciences subject OR equivalent experience Knowledge and Exp
Desirable
- Experience of working in a GMP (Good Manufacture Practice) lab environment or in a 'clean room' environment
Person Specification
qualification
Essential
- Relevant PhD in appropriate Biomedical Engineering/Life Sciences subject OR equivalent experience Knowledge and Exp
Desirable
- Experience of working in a GMP (Good Manufacture Practice) lab environment or in a 'clean room' environment
Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the UK Visas and Immigration website (Opens in a new tab).
From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab).
Additional information
Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the UK Visas and Immigration website (Opens in a new tab).
From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab).
Employer details
Employer name
King's College Hospital NHS Foundation Trust
Address
King's College Hospital NHS Foundation Trust
Denmark Hill
London
SE5 9RS
Employer's website
https://www.kch.nhs.uk/ (Opens in a new tab)
