Job summary
This is an exciting opportunity for a fellow with an interest in sleep ventilation and respiratory medicine to work with key investigators in carrying out new research studies.
The post holder will be able to support the design and conduct of the research with the key investigators. They will also be expected to analysedata, take part in research meetings and prepare manuscripts arising from the research.
The post holder will also support the overall oversight of the conduct of a multisite UK trial with trial Sponsor
Main duties of the job
To set up and deliver the randomised controlled trial (RCT) to investigate the use of transcutaneous electrical stimulation in patients with obstructive sleep apnoea (TESLA-MICRON; NIHR funded) under the supervision of the principal / chief investigator
About us
Guy's and St Thomas' NHS Foundation Trust comprises five of the UK's best known hospitals - Guy's, St Thomas', Evelina London Children's Hospital, Royal Brompton and Harefield - as well as community services in Lambeth and Southwark, all with a long history of high quality care, clinical excellence, research and innovation.Lane Fox Respiratory Service is situated in St Thomas' Hospital and is a specialist commissioned respiratory service to support both the acute and long-term management of patients with sleep disordered breathing andchronic respiratory failure. Currently, there are approximately 2500 patients managed in the Lane Fox Respiratory Service. With 34 beds and a purpose-built outpatient facility, Lane Fox is the largest weaning, rehabilitation and home ventilation service in the UK with a South East HMV network being developed to facilitate ease of access for all patients with chronic respiratory failure.The research service is housed in the Lane Fox Clinical Respiratory Physiology Centre and the translational science programme is focused on three themes of admission prevention in COPD, prevention of skeletal muscle wasting during critical illness and clinical trials to improve long term outcome in patients with sleep disordered breathing and chronic respiratory failure. The Lane Fox Respiratory Service ensures life-long support for patients throughout the cycle of their condition.
Job description
Job responsibilities
o Duties will include, but are not limited to:
-
-
- Screening and recruitment of potentially eligible patients in respiratory / sleep medicine,
- Consent and enrolment of participants,
- Support of randomisation process,
- Support, follow-up and clinical assessment of enrolled study participants according to the study protocol,
- Liaison with R&D team and collaborators,
- Collection and quantitative / qualitative analysis of study data and maintenance of database,
- Preparation of study documents, R&D and ethics applications and approvals, study materials and reports,
- Working with key stakeholders, including sponsor (Zeus), funder (NIHR), and patients / public (PPIE),
- Overseeing trial management at other sites and troubleshooting,
- Preparation of documentation required by sponsor, funder, MHRA, REC and R&D,
- Presentation and dissemination of results and progress / findings via multiple media, including conference presentation (abstracts) and research manuscript publication(s),
- Clinical trial management and conduct according to GCP principles.
To support recruitment, consenting and randomisation to a UK-based, multi-centre randomised controlled trial (RCT). To communicate with patients / participants related to the intervention / usual care, and organise follow up / sleep studies / assessments. To attend relevant site visits (UK wide), trial steering committee (TSC) and data monitoring committee (DMC) meetings. To document case report forms (CRFs) and adverse events (AE). To adhere to GCP and HTA guidelines at all times. To work with R&D, REC and HRA to ensure appropriate authorisations are in place to proceed with the research. To participate in clinical and other service activities with the object of ensuring a high standard of patient care. To participate in undergraduate and postgraduate teaching and training.
Job description
Job responsibilities
o Duties will include, but are not limited to:
-
-
- Screening and recruitment of potentially eligible patients in respiratory / sleep medicine,
- Consent and enrolment of participants,
- Support of randomisation process,
- Support, follow-up and clinical assessment of enrolled study participants according to the study protocol,
- Liaison with R&D team and collaborators,
- Collection and quantitative / qualitative analysis of study data and maintenance of database,
- Preparation of study documents, R&D and ethics applications and approvals, study materials and reports,
- Working with key stakeholders, including sponsor (Zeus), funder (NIHR), and patients / public (PPIE),
- Overseeing trial management at other sites and troubleshooting,
- Preparation of documentation required by sponsor, funder, MHRA, REC and R&D,
- Presentation and dissemination of results and progress / findings via multiple media, including conference presentation (abstracts) and research manuscript publication(s),
- Clinical trial management and conduct according to GCP principles.
To support recruitment, consenting and randomisation to a UK-based, multi-centre randomised controlled trial (RCT). To communicate with patients / participants related to the intervention / usual care, and organise follow up / sleep studies / assessments. To attend relevant site visits (UK wide), trial steering committee (TSC) and data monitoring committee (DMC) meetings. To document case report forms (CRFs) and adverse events (AE). To adhere to GCP and HTA guidelines at all times. To work with R&D, REC and HRA to ensure appropriate authorisations are in place to proceed with the research. To participate in clinical and other service activities with the object of ensuring a high standard of patient care. To participate in undergraduate and postgraduate teaching and training.
Person Specification
Qualifications
Essential
- oMembership of the Royal College of Physicians (UK) or equivalent
Desirable
- oAcademic qualifications (e.g., MD, PhD)
Clinical Experience
Essential
- oExperience of managing patients with obstructive sleep apnoea (OSA)
- oExperience in CPAP / non-CPAP therapies
Desirable
- oExpertise in sleep medicine (e.g., somnologist, ESRS exams)
Knowledge and Skills
Essential
- oExcellent interpersonal skills, including confident and comfortable interaction with trial participants, clinical and research team members, and the broader research community
Desirable
- oFluent use of IT including email, MS Word / MS Excel processing, spreadsheet, database, other library and statistical software packages
Research Skills
Essential
- oUnderstanding of the principles and applications of clinical research
Desirable
- oPrevious study setup and experience with REC/R&D
Other
Essential
- oEvidence of understanding of the role of clinical management
- oEvidence of contribution to effective clinical audit and clinical risk management
Desirable
- oExperience in clinical guideline development
Person Specification
Qualifications
Essential
- oMembership of the Royal College of Physicians (UK) or equivalent
Desirable
- oAcademic qualifications (e.g., MD, PhD)
Clinical Experience
Essential
- oExperience of managing patients with obstructive sleep apnoea (OSA)
- oExperience in CPAP / non-CPAP therapies
Desirable
- oExpertise in sleep medicine (e.g., somnologist, ESRS exams)
Knowledge and Skills
Essential
- oExcellent interpersonal skills, including confident and comfortable interaction with trial participants, clinical and research team members, and the broader research community
Desirable
- oFluent use of IT including email, MS Word / MS Excel processing, spreadsheet, database, other library and statistical software packages
Research Skills
Essential
- oUnderstanding of the principles and applications of clinical research
Desirable
- oPrevious study setup and experience with REC/R&D
Other
Essential
- oEvidence of understanding of the role of clinical management
- oEvidence of contribution to effective clinical audit and clinical risk management
Desirable
- oExperience in clinical guideline development
Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the UK Visas and Immigration website (Opens in a new tab).
From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab).
UK Registration
Applicants must have current UK professional registration. For further information please see
NHS Careers website (opens in a new window).
Additional information
Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the UK Visas and Immigration website (Opens in a new tab).
From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab).
UK Registration
Applicants must have current UK professional registration. For further information please see
NHS Careers website (opens in a new window).
