Senior Genomics Technician

Guy's and St Thomas' NHS Foundation Trust

This job is now closed

Job summary

We are seeking to appoint a highly motivated Senior Genomics Technician to work within the Genomics Research Platform and Single Cell Laboratory, based within the R&D Department at Guy's and St Thomas' NHS Foundation Trust. Our lab uses state-of-the-art genomics technologies to enable fast tracking of research into clinics. The role calls for someone with a keen interest in genomics, preferably with some experience in NGS or single cell technologies or histology techniques to support our service provision to facilitate clinical and academic research with the ultimate aim of improving patient outcome

Main duties of the job

As Senior Genomics Technician, you will undertake assigned scientific projects using a wide range of genomics workflows. These may include single cell, bulk cells and spatial transcriptomics experiments. You would be expected to contribute to optimization of workflows for R&D projects and emerging cutting-edge technologies. You will contribute to the various support and training tasks as part of a team to ensure outputs are delivered timely and effectively.You will hold at least a BSc (or equivalent) in Biology/Life Sciences or relevant discipline plus experience gained through working in a research/service lab. Knowledge, skills and experience in genomics techniques is essential.

Key responsibilities:

Conduct experiments for assigned projects using existing SOPs with attention to detail
Conduct experiments for single cell transcriptomics, spatial transcriptomics using workflows established in the la
Process samples for bulk DNA and RNA sequencing using workflows established in the lab
Ensure project records are accurate, up-to-date and complete
Operation and day-to-day maintenance of equipment within the lab
Conduct R&D projects to optimize and validate new workflows and technologies
Liaise with the bioinformatician to ensure timely delivery of data and completion of projects
Work with researchers and team members to understand work requirements and priorities and be responsive to changing priorities

About us

The Genomics Research Platform at Guy's & St Thomas' NHS Foundation Trust (GSTFT) and King's College London (KCL) is a collaboration between one of the largest and most successful hospitals in the UK, GSTFT, and one of the world's top universities, KCL. The Genomics Research Platform operates as a service provision lab and as an R&D lab. Our team of highly trained scientists with expertise in single cell genomics and next generation sequencing supported by a streamlined bioinformatics service provision facilitates broad range translational research studies. This is an exciting and challenging role which will require string technical and communication skills.

Date posted

04 December 2024

Pay scheme

Agenda for change

Band

Band 6

Salary

£44,806 to £53,134 a year per annum inc HCA

Contract

Permanent

Working pattern

Full-time

Reference number

196-RD208

Job locations

10th Floor, Guy's Tower Wing

Great Maze Pond

London

SE1 9RT

Job description

Job responsibilities

The Genomics Research Platform at Guys & St. Thomas Trust (GSTT) and Kings College London (KCL) is offering a permanent position for a Senior Genomics Technician to conduct day to day services and R&D projects. This is an exciting opportunity for someone with a keen interest in genomics and looking to develop their career in this rapidly developing field. The candidate will work as part of a service team using a range of molecular biology techniques for processing samples using the latest genomics platforms and technologies.

The role calls for a detail oriented, highly motivated and fast learning individual with 3+ years of experience in genomics/molecular biology workflows. Eligible candidates will have a BSc/PhD in Biomedical Science or equivalent with proven experience in molecular biology workflows. Past experience in a research/service provision lab and experience in manual or automated library preparation for NGS is essential while experience in using single cell related platforms will be desirable. An ability to receive training, be closely supervised during the training period, follow SOPs in a word or worksheet format with attention to detail and to complete projects within given timelines and budget is essential. You must be comfortable working in a multidisciplinary environment, have excellent communication and customer service skills, and be comfortable working independently.

Key responsibilities include

Provide genomics services to platform users as required these include single cell transcriptomics profiling, spatial transcriptomics profiling, bulk cell DNA and RNA sequencing
Maintain detailed records of the laboratory work and service operations for assigned projects undertaken by the post-holder
Participate in group meetings, presentations and discussions of experimental data
Work synergistically with other team members and key stakeholders within GSTT and KCL to ensure smooth operation and streamlined genomics service provision
Contribute to development of new SOPs and protocols

For informal enquiries please contact pawan.dhami@gstt.nhs.uk

Job description

Job responsibilities

Key responsibilities include

Provide genomics services to platform users as required these include single cell transcriptomics profiling, spatial transcriptomics profiling, bulk cell DNA and RNA sequencing
Maintain detailed records of the laboratory work and service operations for assigned projects undertaken by the post-holder
Participate in group meetings, presentations and discussions of experimental data
Work synergistically with other team members and key stakeholders within GSTT and KCL to ensure smooth operation and streamlined genomics service provision
Contribute to development of new SOPs and protocols

For informal enquiries please contact pawan.dhami@gstt.nhs.uk

Person Specification

Qualifications/Education

Essential

Degree level education in relevant discipline (e.g. Biology, Life Sciences)

Desirable

Masters in relevant discipline (e.g. Biology, Life Sciences)

Experience

Essential

Experience in library preparation for NGS
Experience in wet-lab molecular workflows (e.g. DNA/RNA extractions, qPCR, sample QC)
Experience in operating Illumina sequencing platforms

Desirable

Experience in service provision lab
Experience in single cell NGS workflows
Experience in spatial transcriptomics workflows
Experience in long read sequencing technologies (e.g. Nanopore or PacBio)

Skills

Essential

Be able to follow standard operating procedures
Ability to prioritize and meet deadlines

Desirable

Operating complex equipment (e.g. Tapestation, Bioanalyser, Covaris etc)

Person Specification

Qualifications/Education

Essential

Degree level education in relevant discipline (e.g. Biology, Life Sciences)

Desirable

Masters in relevant discipline (e.g. Biology, Life Sciences)

Experience

Essential

Experience in library preparation for NGS
Experience in wet-lab molecular workflows (e.g. DNA/RNA extractions, qPCR, sample QC)
Experience in operating Illumina sequencing platforms

Desirable

Experience in service provision lab
Experience in single cell NGS workflows
Experience in spatial transcriptomics workflows
Experience in long read sequencing technologies (e.g. Nanopore or PacBio)

Skills

Essential

Be able to follow standard operating procedures
Ability to prioritize and meet deadlines

Desirable

Operating complex equipment (e.g. Tapestation, Bioanalyser, Covaris etc)

Disclosure and Barring Service Check

This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.

Certificate of Sponsorship

Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the UK Visas and Immigration website (Opens in a new tab).

From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab).

Additional information