Clinical Research Fellow in Cystic Fibrosis

Guy's and St Thomas' NHS Foundation Trust

This job is now closed

Job summary

This post offers an exciting opportunity to work in cystic fibrosis, focusing on cutting-edge diagnostic techniques, with the aim of obtaining a post graduate degree (PhD) from Imperial College London. It is ideally suited for a respiratory (adult or paediatric) trainee wishing to undertake Out of Programme (OOP) training in clinical research with a focus on advanced diagnostics and personalised medicine by developing and validating novel methods such as organoid technology. It could also suit gastroenterology trainees. This has been made possible by a CF Trust-Funded Development Award which includes world experts in CF organoid technology from Utrecht Medical Centre (UMC), Netherlands, and co-investigators from Kings College London, Imperial College London and Kings College Hospital. The successful candidate will also have an opportunity to contribute to our highly successful Clinical Trials Team and experience all aspects of CF care, with its multi-disciplinary team approach.

Main duties of the job

This the predominant role of the post is research. The post holder will be supported towards obtaining a PhD degree from Imperial College London. As outlined above, the post holder will have the opportunity to develop and validate novel techniques, centred around organoid technology, to improve the diagnostic outcomes in CF and 'CF-like' conditions, including bronchiectasis. The role will include writing study protocols, submissions to ethics committees and ultimately completion of the research project, with supervisor support. The post holder will work collaboratively with other scientists from Kings College London and have direct support from experts from UMC, Netherlands.

About us

Royal Brompton Hospital is the largest postgraduate specialist heart and lung centre in the United Kingdom. A fundamental strength of the hospital is close collaboration between the various clinical specialities which cover all aspects of heart and lung disease and collaboration on basic science research with the National Heart and Lung Institute. The hospital enjoys first rate diagnostic and clinical support services, and services are organised into a clinical directorate structure, with each directorate led by a clinical director.

The Royal Brompton Hospital adult and paediatric CF centres are among the largest in Europe with approximately 900 CF patients and 100 CFTR-Related Disorder patients. It has a reputation for high quality clinical care and research. It has a unique national 'Difficult CF Diagnosis' (DCFD) service, using state-of-the art diagnostic techniques including novel genomics and functional tests, including nasal potential difference measurement.

Date posted

17 October 2024

Pay scheme

Hospital medical and dental staff

Grade

Doctor - other

Salary

Depending on experience Dependent on ST level

Contract

Fixed term

Duration

3 years

Working pattern

Full-time

Reference number

196-MED4598

Job locations

Adult Cystic Fibrosis Centre

Royal Brompton Hospital

London

SW3 6NP

Job description

Job responsibilities

Additional tasks/roles will include:

o Developing clinical expertise in organoid biopsy sampling, preparation and analysis. There will be an opportunity to learn some of the lab techniques, as indicated.

o Acquiring new clinical/research skills, such as nasal potential difference measurement and supporting the development of the intestinal current measurement service.

o Writing a PhD proposal, early/late stage reviews, regular reports and thesis.

o Acquiring transferable generic research skills, such as critical reading, data analysis, data interpretation, data presentation etc.

o Preparing for and attending regular research meetings

o Contributing to the clinical trials portfolio; working as a sub-investigator on commercial and academic clinical trials (e.g. study visits, recruitment, reviewing and grading adverse events; communicating closely with the principal investigator, and liaising with sponsors and Clinical Research Organisations)

o Studying for and obtaining Good Clinical Practice (GCP) certification and consent training, as well as attending mandatory postgraduate degree training courses

Clinical The Fellow will be expected to cover one out-patient clinic per week, with flexibility to attend other clinics and ward rounds, when research workload permits. They will also be required to attend monthly nasal potential clinics and DCFD meetings.

Job description

Job responsibilities

Additional tasks/roles will include:

o Developing clinical expertise in organoid biopsy sampling, preparation and analysis. There will be an opportunity to learn some of the lab techniques, as indicated.

o Acquiring new clinical/research skills, such as nasal potential difference measurement and supporting the development of the intestinal current measurement service.

o Writing a PhD proposal, early/late stage reviews, regular reports and thesis.

o Acquiring transferable generic research skills, such as critical reading, data analysis, data interpretation, data presentation etc.

o Preparing for and attending regular research meetings

o Studying for and obtaining Good Clinical Practice (GCP) certification and consent training, as well as attending mandatory postgraduate degree training courses

Person Specification

Person specification

Essential

Qualifications

Person specification

Essential

Qualifications
Clinical Experience
Clinical skills, knowledge and ability
Research
Personal skills
Other - GMC

Desirable

Qualifications - GCP
CLinical experience - ALS
Research - publications, trials

Research

Essential

oInterest in, and an ability to initiate & conduct research
oAttention to detail and meticulous record keeping

Research

Desirable

Published research
Involvement in clinical trials

Person Specification

Person specification

Essential

Qualifications

Person specification

Essential

Qualifications
Clinical Experience
Clinical skills, knowledge and ability
Research
Personal skills
Other - GMC

Desirable

Qualifications - GCP
CLinical experience - ALS
Research - publications, trials

Research

Essential

oInterest in, and an ability to initiate & conduct research
oAttention to detail and meticulous record keeping

Research

Desirable

Published research
Involvement in clinical trials

Disclosure and Barring Service Check

This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.

Certificate of Sponsorship

Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the UK Visas and Immigration website (Opens in a new tab).

From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab).