Job summary
This post offers an exciting opportunity to join our large Adult CF Centre as a Clinical Fellow. This is a unique opportunity to combine cutting edge diagnostic CFTR research with clinical outcomes and the important emerging field of CFTR-related disorders, as the successful candidate will have the opportunity to work in our state-of-the-art 'Difficult CF Diagnosis' service. In addition, the successful candidate will have an opportunity to contribute to our highly successful Clinical Trials Team and experience all aspects of CF care, with its multi-disciplinary team approach, cross-cutting effectively with clinical research.
Main duties of the job
The main duty will be to develop clinical and research expertise in CF care and diagnostics by working with the CF/diagnostics teams. The post holder will be trained to become proficient in diagnostic techniques, such as nasal PD. They will attend weekly Difficult CF Diagnosis (DCFD) and CFTR-Related Disorders clinics, in addition to monthly nasal PD clinics.
If desired, they will also be able to attend paediatric clinics to gain CFSPID (CF screen positive inconclusive diagnosis) experience and further their CF knowledge. They will also attend monthly DCFD Consensus Meetings, which includes genetic expertise as well as CF clinicians, nurses and genetic counsellors.
To support this, they will also be involved with general CF clinics x1 per week. Alongside clinical duties and clinical trial activities, there will be ample opportunity and an expectation to develop research projects, write abstracts, papers, protocols, ethics submissions and develop guidelines. Further development into a higher degree (e.g. MD (Res)) could be considered.
About us
Royal Brompton Hospital is the largest postgraduate specialist heart and lung centre in the United Kingdom. The hospital enjoys first rate diagnostic and clinical support services, and services are organised into a clinical directorate structure, with each directorate led by a clinical director.
The Royal Brompton Hospital adult and paediatric CF centres are among the largest in Europe with approximately 900 CF patients, 100 CFTR-Related Disorder patients and 20 children with CFSPID (CF screen positive inconclusive diagnosis). It has a reputation for high quality clinical care and research. It has a unique 'Difficult CF Diagnosis' (DCFD) service, using state-of-the art diagnostic techniques including novel genomics and functional tests, including nasal potential difference (PD) measurement.
It is also in the process of setting up intestinal current measurement (ICM) and has ambitions to develop rectal organoids as a diagnostic test, working closely with the European CF Society (ECFS) Diagnostic Network Working Group. It also has a very active clinical trials team which is a member of the ECFS Clinical Trials Network and the CF Trust-sponsored Clinical Trials Accelerator Platform (CTAP). Both the diagnostic service and clinical trials teams work across the age spectrum. The hospital has close links with Imperial College London through the National Heart and Lung Institute (NHLI).
Job description
Job responsibilities
Additional tasks/roles will include:
- Acquiring new clinical skills, such as nasal PD and intestinal current measurement, as well as developing in-depth knowledge of respiratory genetics/genomics.
- Acquiring and developing CF and CFTR-RD knowledge and skills.
- Acquiring transferable generic research skills, such as critical reading, data analysis, data interpretation, data presentation etc.
- Contributing to the clinical trials portfolio; working as a sub-investigator on commercial and academic clinical trials (e.g. study visits, recruitment, reviewing and grading adverse events; communicating closely with the principal investigator, and liaising with sponsors and Clinical Research Organisations)
- Studying for and obtaining Good Clinical Practice (GCP) certification and consent training, as well as attending mandatory postgraduate degree training courses
Clinical The Fellow will be expected to cover one diagnostic clinic and one adult CF out-patient clinic per week, with flexibility to attend other clinics and ward rounds, when workload permits. They will also be required to attend monthly nasal PD clinic and prepare and attend monthly DCFD meetings.
On Call - None formally included, but there could be an opportunity for ad hoc rota gap cover.
Education and Training
Both Adult and Paediatric departments have regular teaching activities which the Fellow would be encouraged to attend. There are weekly respiratory seminars run through the Respiratory Clinical Research Facility.
The National Heart and Lung Institute has excellent facilities for studying and an extensive library with all the current journals and textbooks. The National Heart and Lung Institute is part of Imperial College, which greatly enhances the facilities available for studying and research.
Numerous postgraduate courses are held in the National Heart and Lung Institute and the CF Department takes an active part. Postgraduate students are attached to the Department and receive tutorials and ward rounds from members of the Department.
Job description
Job responsibilities
Additional tasks/roles will include:
- Acquiring new clinical skills, such as nasal PD and intestinal current measurement, as well as developing in-depth knowledge of respiratory genetics/genomics.
- Acquiring and developing CF and CFTR-RD knowledge and skills.
- Acquiring transferable generic research skills, such as critical reading, data analysis, data interpretation, data presentation etc.
- Contributing to the clinical trials portfolio; working as a sub-investigator on commercial and academic clinical trials (e.g. study visits, recruitment, reviewing and grading adverse events; communicating closely with the principal investigator, and liaising with sponsors and Clinical Research Organisations)
- Studying for and obtaining Good Clinical Practice (GCP) certification and consent training, as well as attending mandatory postgraduate degree training courses
Clinical The Fellow will be expected to cover one diagnostic clinic and one adult CF out-patient clinic per week, with flexibility to attend other clinics and ward rounds, when workload permits. They will also be required to attend monthly nasal PD clinic and prepare and attend monthly DCFD meetings.
On Call - None formally included, but there could be an opportunity for ad hoc rota gap cover.
Education and Training
Both Adult and Paediatric departments have regular teaching activities which the Fellow would be encouraged to attend. There are weekly respiratory seminars run through the Respiratory Clinical Research Facility.
The National Heart and Lung Institute has excellent facilities for studying and an extensive library with all the current journals and textbooks. The National Heart and Lung Institute is part of Imperial College, which greatly enhances the facilities available for studying and research.
Numerous postgraduate courses are held in the National Heart and Lung Institute and the CF Department takes an active part. Postgraduate students are attached to the Department and receive tutorials and ward rounds from members of the Department.
Person Specification
Qualifications
Essential
- MBBS or equivalent
- MRCP, MRCPCH or equivalent
Desirable
Clinical Experience
Essential
- Adult respiratory medicine
- Cystic fibrosis
Research
Essential
- Interest in, and an ability to initiate & conduct research
- Attention to detail and meticulous record keeping
Desirable
- Published research
- Involvement in clinical trials
Person Specification
Qualifications
Essential
- MBBS or equivalent
- MRCP, MRCPCH or equivalent
Desirable
Clinical Experience
Essential
- Adult respiratory medicine
- Cystic fibrosis
Research
Essential
- Interest in, and an ability to initiate & conduct research
- Attention to detail and meticulous record keeping
Desirable
- Published research
- Involvement in clinical trials
Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
UK Registration
Applicants must have current UK professional registration. For further information please see
NHS Careers website (opens in a new window).
Additional information
Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
UK Registration
Applicants must have current UK professional registration. For further information please see
NHS Careers website (opens in a new window).
