Job summary
We seek a dedicated clinical research fellow with a career interest in hepatology, to undertake a specified programme of research activity, under a project titled:
Characterising the burden and clinical trajectory in chronic cholestatic diseases. The University of Birmingham and University Hospitals' Birmingham NHS Foundation Trust have a strong pedigree of innovation and research excellence in cholestatic liver disease; both at the individual centre level and as part of multicentre collaborative platforms. Our track record is exemplified by high-level clinical trial activity, quality evidence to guide clinical practice, and development of risk stratification algorithms that define treatment response for patients.
Main duties of the job
The principled intent of this programme is to characterise the prevalence of pruritus and its severity, how this varies over time as per the clinical course of primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC) and genetic disorders of cholestasis. This is with a particular view to assess use and effectiveness of current therapeutic interventions. In parallel, the project will detail epidemiological trends in these conditions, and how the incidence and prevalence are changing over time. The appointee will also be expected to support the clinical cholestatic disease service, which includes specialist outpatient clinics and multi-disciplinary team meetings and a large portfolio of clinical trial activity.
Specific objectives will be to:
*Study the real-world experience and efficacy of therapeutic interventions in chronic cholestatic liver disease, at a local, regional and national level.
*Assess how the epidemiology has changed, is changing now, and predicted to change over time.
*Determine how changes in disease epidemiology are likely to impact need for newly licensed medicines in cholestatic diseases.
*Participate in quality improvement and service delivery, as part of the dedicated Clinical Cholestasis programme.
*Ensure effective running of liver clinical trials as part of the University of Birmingham BRC
About us
University Hospitals Birmingham NHS Foundation Trust strives to have an inclusive culture where everyone feels like they belong, can thrive, knows that they add value and feels valued. We do this by developing compassionate and culturally competent leaders, being values driven in all that we do and by creating a welcoming and inclusive workplace that thrives on the diversity of our people. As such we want to attract and recruit talented individuals from all backgrounds, and for each of you to feel supported for the diversity you bring, to achieve your full potential. For those staff with a disability, including physical disability, long term health condition, mental health or neurodiverse condition, this also means being committed to making reasonable adjustments needed for you to carry out your role.
Job description
Job responsibilities
*Establish clinical research in an agreed area, including collection and analysis of critical data.
*Gain sufficient research experience that will enable completion of a higher degree (MD or PhD).
*Facilitate trial set-up and obtain necessary approvals (ethics, MHRA) for nested cohort studies.
*Prioritise tasks within the agreed work schedule to ensure that projects are delivered in timely fashion, in accordance to set deadlines.
*Suggest and contribute to the development of research techniques, models and methods in collaboration with colleagues.
*Contribute to writing ethics' submissions and bids for research grants.
*Disseminate research findings using appropriate and effective media such as publication, research seminars and conference presentations.
*Provide guidance to other staff and students.
*Contribute to the production of research reports.
*Plan and develop research contributions to subject area using methodologies, critical evaluations, interpretations, analyses and other appropriate techniques.
*Organise and lead patient and public involvement focus groups.
*Work together with the project team (locally and internationally) to yield high impact publication outputs, and generate novel data for future grant applications.
Job description
Job responsibilities
*Establish clinical research in an agreed area, including collection and analysis of critical data.
*Gain sufficient research experience that will enable completion of a higher degree (MD or PhD).
*Facilitate trial set-up and obtain necessary approvals (ethics, MHRA) for nested cohort studies.
*Prioritise tasks within the agreed work schedule to ensure that projects are delivered in timely fashion, in accordance to set deadlines.
*Suggest and contribute to the development of research techniques, models and methods in collaboration with colleagues.
*Contribute to writing ethics' submissions and bids for research grants.
*Disseminate research findings using appropriate and effective media such as publication, research seminars and conference presentations.
*Provide guidance to other staff and students.
*Contribute to the production of research reports.
*Plan and develop research contributions to subject area using methodologies, critical evaluations, interpretations, analyses and other appropriate techniques.
*Organise and lead patient and public involvement focus groups.
*Work together with the project team (locally and internationally) to yield high impact publication outputs, and generate novel data for future grant applications.
Person Specification
Qualifications
Essential
- *MBBS, MBChB (or equivalent)
- *Candidates should be registered with the GMC with a License to Practice.
- *Completion of MRCP or equivalent
Experience
Essential
- *Applicant should ideally be on the Specialty Training Programme for Gastroenterology, with at least one year completion of specialist registrar/ST3 training or equivalent) by time of appointment.
- *Demonstrate an existing interest in basic, translational of clinical research, as evidenced by contribution to at least one previous research publication or conference abstract at a national/international level.
Additional Criteria
Essential
- Please see attached Job Description for further details about this role or contact the named consultant for a discussion about this post.
Person Specification
Qualifications
Essential
- *MBBS, MBChB (or equivalent)
- *Candidates should be registered with the GMC with a License to Practice.
- *Completion of MRCP or equivalent
Experience
Essential
- *Applicant should ideally be on the Specialty Training Programme for Gastroenterology, with at least one year completion of specialist registrar/ST3 training or equivalent) by time of appointment.
- *Demonstrate an existing interest in basic, translational of clinical research, as evidenced by contribution to at least one previous research publication or conference abstract at a national/international level.
Additional Criteria
Essential
- Please see attached Job Description for further details about this role or contact the named consultant for a discussion about this post.
Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the UK Visas and Immigration website (Opens in a new tab).
From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab).
UK Registration
Applicants must have current UK professional registration. For further information please see
NHS Careers website (opens in a new window).
Additional information
Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the UK Visas and Immigration website (Opens in a new tab).
From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab).
UK Registration
Applicants must have current UK professional registration. For further information please see
NHS Careers website (opens in a new window).
