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NB: This vacancy closed to applications on 22/05/2019.

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Molecular Therapy Advanced Specialist

Job Reference: 918-HM4283

NHS Blood and Transplant (NHSBT)
Bristol - Filton
£37,570 to £43,772 pa

This vacancy is on a fixed term/ secondment basis for 12 months. Secondments will be considered for NHSBT staff wishing to apply for this role. Please discuss the possibility of a secondment with your current line manager before applying.


The Clinical Biotechnology Centre (CBC), part of Cellular and Molecular Therapies (CMT) of NHSBT, is a specialist manufacturer of advanced therapies including both the production and testing of novel recombinant proteins and gene therapy products for clinical trials. CBC also has a product development department working with a number of external partners to translate R&D to the clinic. CBC will be expanding into Lentiviral and therapeutic RNA production, which will take place in a new specialised facility based at NHSBT Filton. For this and other similar projects, we are seeking to enlist an additional senior development scientist.


The post holder will be responsible for development work in establishing processes used for GMP-grade RNA manufacturing. A large part of this post will be dedicated to the development of sensitive and robust assays to ensure product quality and consistency. An understanding of the quality control requirements for process and product qualification to GMP is essential. A practical background in techniques such as in vitro transcription, large-scale RNA purification (tangential flow filtration) and RNA analysis at the molecular level is essential. In addition, detailed knowledge and practical experience in process development and modelling are required. Previous experience in protein engineering and purification is required as well as experience in molecular cloning. Experience in next generation sequencing techniques is advantageous. Prior experience in delivery of specified products to clients is highly desirable, as well as in-depth understanding of the quality control requirements for fully GMP-qualified processes.


Reporting directly to the Lead Development Scientist, the post holder will be responsible for the planning and monitoring of development and QC work and also actively participate in reporting and meetings internally and with collaborators.


The normal working hours for this role are 37.5 hours per week, Monday – Friday.


If you would like to discuss this vacancy in more detail, please contact Piers Walser via email at:


This vacancy will close at 23:59 on Wednesday 22nd May 2019, with interviews scheduled to take placeW/c 3rd June 2019 (subject to confirmation).


NHS Blood and Transplant (NHSBT) offers a dynamic and friendly working environment where teamwork is highly valued. Personal development is also considered a priority and is supported through extensive training and development opportunities open to all employees.

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