Job summary
A GMP scientist position is available within the Centre for Cell, Gene & Tissue Therapeutics. The post holder will be responsible for supporting a new, GMP-compliant lentiviral manufacturing facility in brand new, purpose-built clean rooms and assisting the development and implementation of novel intermediate scale lentiviral manufacturing techniques in suspension cell bioreactors.
The Post Holder will be responsible for GMP manufacture of lentiviral vector, and supporting the process development team transfer the process to GMP.
The post holder will also help to develop new downstream purification and packaging systems for the delivery of GMP-compliant lentiviral vectors to the cell manufacturing teams in the CCGTT.
Main duties of the job
The post requires exceptional attention to detail and the ability to work in a systematic manner whilst keeping detailed records. Perform QC testing on viral vectors: including flow cytometry, sterility testing and enumeration of viral preps and collating complex batch data for analysis and to interpret for final reporting. Calibration and maintenance of equipment for production and testing is required to maintain the laboratory.
Technical expertise in the in vitro culture of adherent and suspension cells and the ability to communicate ideas and practical skills to co-workers both at the bench and in formal presentations.
The post holder will be responsible to the Director of Vector for ensuring that the vector production laboratory is compliant with current legislation and best practice and will participate in the statutory regulatory inspections by MHRA.
About us
Work will be performed in the Royal Free Hospital, Hampstead within the newly established viral vector team under the CCGTT umbrella
Job description
Job responsibilities
The post requires exceptional attention to detail and the ability to work in a systematic manner whilst keeping detailed records. Perform QC testing on viral vectors: including flow cytometry, sterility testing and enumeration of viral preps and collating complex batch data for analysis and to interpret for final reporting. Calibration and maintenance of equipment for production and testing is required to maintain the laboratory.
Technical expertise in the in vitro culture of adherent and suspension cells and the ability to communicate ideas and practical skills to co-workers both at the bench and in formal presentations.
The post holder will be responsible to the Director of Vector for ensuring that the vector production laboratory is compliant with current legislation and best practice and will participate in the statutory regulatory inspections by MHRA.
Job description
Job responsibilities
The post requires exceptional attention to detail and the ability to work in a systematic manner whilst keeping detailed records. Perform QC testing on viral vectors: including flow cytometry, sterility testing and enumeration of viral preps and collating complex batch data for analysis and to interpret for final reporting. Calibration and maintenance of equipment for production and testing is required to maintain the laboratory.
Technical expertise in the in vitro culture of adherent and suspension cells and the ability to communicate ideas and practical skills to co-workers both at the bench and in formal presentations.
The post holder will be responsible to the Director of Vector for ensuring that the vector production laboratory is compliant with current legislation and best practice and will participate in the statutory regulatory inspections by MHRA.
Person Specification
Experience
Essential
Desirable
- GMP experience in Vector manufacture
Education
Desirable
Skills
Essential
- Over 1 year of experience in Quality Management System Documentation
Leadership
Essential
- Experience with taking charge of projects
Person Specification
Experience
Essential
Desirable
- GMP experience in Vector manufacture
Education
Desirable
Skills
Essential
- Over 1 year of experience in Quality Management System Documentation
Leadership
Essential
- Experience with taking charge of projects
Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the UK Visas and Immigration website (Opens in a new tab).
From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab).
Additional information
Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the UK Visas and Immigration website (Opens in a new tab).
From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab).
